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Research advances in the transformation of chronic obstructive pulmonary disease to lung cancer
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Wen-min ZHOU1, Qiao-ru GUO1, Hui WANG2, Zeng-bao WU3, Jian-ye ZHANG1, 4, *
Acta Pharmaceutica Sinica | 2020, 55(7) : 1410 - 1418
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Acta Pharmaceutica Sinica | 2020, 55(7): 1410-1418
• Reviews •
Research advances in the transformation of chronic obstructive pulmonary disease to lung cancer
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Wen-min ZHOU1, Qiao-ru GUO1, Hui WANG2, Zeng-bao WU3, Jian-ye ZHANG1, 4, *
Affiliations
  • 1. Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China
  • 2. Guangzhou Institute of Pediatrics/Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China
  • 3. Key Laboratory of Xinjiang Phytomedicine Resources of Ministry of Education, School of Pharmacy, Shihezi University, Shihezi 832003, China
  • 4. Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou 571199, China
Published: 2020-07-12 doi: 10.16438/j.0513-4870.2020-0170
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The incidence and mortality of chronic obstructive pulmonary disease (COPD) and lung cancer are increasing year by year, which are causing massive social and financial burdens around the world. An increasing number of investigations indicate the possibility of COPD transforming into lung cancer. The pathogenesis of these two diseases have some common aspects, such as epithelial-mesenchymal transition, chronic inflammation, DNA damage, impaired immune system, oxidative stress and tumor angiogenesis, which are heavily complicated. This review summarizes the epidemiological connection between COPD and lung cancer, the molecular-level transformation mechanism as well as the therapeutic strategy. Exploring the transformation mechanism and related signaling pathway of COPD to lung cancer can contribute to block the risk factors for the transformation and provide guidance for the novel drug development and drug therapy.

chronic obstructive pulmonary disease  /  lung cancer  /  epidemiology  /  signal transduction  /  drug therapy
Wen-min ZHOU, Qiao-ru GUO, Hui WANG, Zeng-bao WU, Jian-ye ZHANG. Research advances in the transformation of chronic obstructive pulmonary disease to lung cancer[J]. Acta Pharmaceutica Sinica, 2020 , 55 (7) : 1410 -1418 . DOI: 10.16438/j.0513-4870.2020-0170
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Article Info
doi: 10.16438/j.0513-4870.2020-0170
  • Receive Date：2020-02-23
  • Online Date：2026-01-21
  • Published：2020-07-12
Article Data
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History
  • Received：2020-02-23
  • Accepted：2020-03-08
Funding
Affiliations
    1. Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China
    2. Guangzhou Institute of Pediatrics/Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China
    3. Key Laboratory of Xinjiang Phytomedicine Resources of Ministry of Education, School of Pharmacy, Shihezi University, Shihezi 832003, China
    4. Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou 571199, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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