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Analysis of chemical drugs applied for clinical trial for the treatment of COVID-19
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Chao ZHANG1, Shu-bing CHEN2, Jie ZHANG1, Ying GUO2, *
Acta Pharmaceutica Sinica | 2020, 55(3) : 355 - 365
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Acta Pharmaceutica Sinica | 2020, 55(3): 355-365
• Focus on Anti Novel Coronavirus Drugs Research •
Analysis of chemical drugs applied for clinical trial for the treatment of COVID-19
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Chao ZHANG1, Shu-bing CHEN2, Jie ZHANG1, Ying GUO2, *
Affiliations
  • 1. National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • 2. Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2020-03-12 doi: 10.16438/j.0513-4870.2020-0151
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The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout China and many other countries around the world. The antivirals are important measures to this epidemic; however, there is no drug approved for against coronavirus yet. With the continuously rising number of confirmed/suspected cases of COVID-19, it is urgent to obtain antiviral drugs for the clinical treatment. In response to this situation, drug repurposing strategy becomes one of the best approaches for anti-SARS-CoV-2 drug discovery. By retrieving the clinical trials registered in Chinese Clinical Trial Registry and ClinicalTrials.gov, a total of 14 chemical drugs were registered for COVID-19. In this review, we summarize and analyze the 14 drugs' indications, targets, and research basis related to the activities against viral infections, esp. coronavirus infections. We are making efforts to understand the evidence basis of these drugs for the treatment of SARS-CoV-2 infection applied by various research and clinical institutions in response to this COVID-19 outbreak, and also providing clues for quick response to possible epidemic in future and reasonable expansion of the indications of drugs.

coronavirus  /  SARS-CoV-2  /  COVID-19  /  clinical trial  /  drug repurposing
Chao ZHANG, Shu-bing CHEN, Jie ZHANG, Ying GUO. Analysis of chemical drugs applied for clinical trial for the treatment of COVID-19[J]. Acta Pharmaceutica Sinica, 2020 , 55 (3) : 355 -365 . DOI: 10.16438/j.0513-4870.2020-0151
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Article Info
doi: 10.16438/j.0513-4870.2020-0151
  • Receive Date：2020-02-20
  • Online Date：2026-01-20
  • Published：2020-03-12
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  • Received：2020-02-20
  • Revised：2020-02-22
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Affiliations
    1. National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
    2. Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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