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Discovery and identification of a tadalafil analogue
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Ting-ting FENG1, 2, 3, Jian SUN2, Jing-xian ZHANG2, Hong YU2, Rui FENG2, Su ZHANG2, Xiu-hong MAO2, Qing HU2, *, Shen JI1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(8) : 1877 - 1881
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Acta Pharmaceutica Sinica | 2020, 55(8): 1877-1881
Discovery and identification of a tadalafil analogue
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Ting-ting FENG1, 2, 3, Jian SUN2, Jing-xian ZHANG2, Hong YU2, Rui FENG2, Su ZHANG2, Xiu-hong MAO2, Qing HU2, *, Shen JI1, 2, *
Affiliations
  • 1. China State Institute of Pharmaceutical Industry, Shanghai 201203, China
  • 2. Shanghai Institute for Food and Drug Control, NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai 201203, China
  • 3. Hebei North University, Zhangjiakou 075000, China
Published: 2020-08-12 doi: 10.16438/j.0513-4870.2020-0033
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A tadalafil analogue was detected during routine screenings from two "fatigue reliever, immunity enhancer" dietary supplements by using UHPLC/Q-TOF HRMS. The MS2 spectrum of this compound was almost identical to that of 2-hydroxypropylnortadalafil. However, the retention time of this analogue was different from that of the 2-hydroxypropylnortadalafil isomers. The analogue was purified by using preparative HPLC and the structure was elucidated by mass spectrometric and NMR spectroscopic experiments. The spectral data suggested that the analogue bore a 3-hydroxypropyl group instead of the N-methyl group in tadalafil. The structure was further confirmed by comparison of the 1H NMR spectra data with those of the reference standard, and thus named as 3-hydroxypropylnortadalafil. The structure is first reported in China.

tadalafil analogue  /  UHPLC/Q-TOF HRMS  /  PDE-5  /  dietary supplement
Ting-ting FENG, Jian SUN, Jing-xian ZHANG, Hong YU, Rui FENG, Su ZHANG, Xiu-hong MAO, Qing HU, Shen JI. Discovery and identification of a tadalafil analogue[J]. Acta Pharmaceutica Sinica, 2020 , 55 (8) : 1877 -1881 . DOI: 10.16438/j.0513-4870.2020-0033
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Article Info
doi: 10.16438/j.0513-4870.2020-0033
  • Receive Date：2020-01-10
  • Online Date：2026-01-21
  • Published：2020-08-12
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  • Received：2020-01-10
  • Revised：2020-03-25
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Affiliations
    1. China State Institute of Pharmaceutical Industry, Shanghai 201203, China
    2. Shanghai Institute for Food and Drug Control, NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai 201203, China
    3. Hebei North University, Zhangjiakou 075000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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