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Progress in research of N-acetylaspartate in central nervous system
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Lin-yu CAO, Hong-wan DING, Kai-yun YAO, Jian-jun ZHANG, Gui-bin WANG*
Acta Pharmaceutica Sinica | 2020, 55(8) : 1754 - 1761
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Acta Pharmaceutica Sinica | 2020, 55(8): 1754-1761
• Reviews •
Progress in research of N-acetylaspartate in central nervous system
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Lin-yu CAO, Hong-wan DING, Kai-yun YAO, Jian-jun ZHANG, Gui-bin WANG*
Affiliations
  • Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2020-08-12 doi: 10.16438/j.0513-4870.2020-0022
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N-Acetylaspartate (NAA) is a highly abundant brain metabolite. Nowadays, as an important marker reflecting the function of nervous system, NAA is widely used in the results analysis of nuclear magnetic resonance spectroscopy (1H MRS). NAA is synthesized in mitochondria of neurons and metabolized in oligodendrocytes. Additionally, NAA may be converted to the dipeptide N-acetylaspartylglutamate (NAAG), and catabolized into NAA and glutamate in astrocytes. NAA is related to a variety of central nervous system diseases, including Canavan disease, multiple sclerosis, depression, schizophrenia and other mental diseases. Therefore, NAA may be a biomarker of these diseases, and its related enzymes may be used as therapeutic targets for drug screening. Here, we combined the current research on the molecular mechanisms of NAA to reveal the process of NAA generation, metabolism and transport in the brain, explain the possible physiological effects of NAA and discuss its relationship with central nervous system diseases, explore the prospect of NAA in disease prediction and diagnosis, as well as the targeted treatment that may become the breakthrough of refractory diseases.

N-acetylaspartate  /  molecular mechanism  /  physiological action  /  drug target  /  central nervous system
Lin-yu CAO, Hong-wan DING, Kai-yun YAO, Jian-jun ZHANG, Gui-bin WANG. Progress in research of N-acetylaspartate in central nervous system[J]. Acta Pharmaceutica Sinica, 2020 , 55 (8) : 1754 -1761 . DOI: 10.16438/j.0513-4870.2020-0022
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Article Info
doi: 10.16438/j.0513-4870.2020-0022
  • Receive Date：2020-01-07
  • Online Date：2026-01-21
  • Published：2020-08-12
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  • Received：2020-01-07
  • Accepted：2020-02-23
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    Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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