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An update on New Delhi metallo-β-lactamase-1 and its inhibitors
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Wen-bin JIN1, 2, Jiang LI1, Jiao LI1, Ling-yun CHEN1, 2, An-guo HOU1, 2, *, Yun-shu MA1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(6) : 1157 - 1165
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Acta Pharmaceutica Sinica | 2020, 55(6): 1157-1165
• Reviews •
An update on New Delhi metallo-β-lactamase-1 and its inhibitors
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Wen-bin JIN1, 2, Jiang LI1, Jiao LI1, Ling-yun CHEN1, 2, An-guo HOU1, 2, *, Yun-shu MA1, 2, *
Affiliations
  • 1. Yunnan University of Chinese Medicine, Kunming 650500, China
  • 2. Key Laboratory of Applied Drug Delivery System and Preparation Technology, Kunming 650500, China
Published: 2020-06-12 doi: 10.16438/j.0513-4870.2019-1049
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The rapid development of antibiotic resistance among bacterial pathogens has threatened to take humans back to the "pre-antibiotic era". The New Delhi metallo-β-lactamase (NDM-1) hydrolyzes nearly all β-lactam antibiotics including carbapenems. Bacterial strains carrying blaNDM-1 gene are termed "superbugs" and clinical inhibitors of NDM-1 have not yet been identified. Discovery of novel NDM-1 inhibitors is a challenging but rewarding research area. This review focuses on the structural characteristics and catalytic mechanisms of NDM-1, and comprehensively summarizes the development of NDM-1 inhibitors in order to facilitate the further development of NDM-1 inhibitors.

superbug  /  β-lactamase  /  New Delhi metallo-β-lactamase  /  inhibitor
Wen-bin JIN, Jiang LI, Jiao LI, Ling-yun CHEN, An-guo HOU, Yun-shu MA. An update on New Delhi metallo-β-lactamase-1 and its inhibitors[J]. Acta Pharmaceutica Sinica, 2020 , 55 (6) : 1157 -1165 . DOI: 10.16438/j.0513-4870.2019-1049
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Article Info
doi: 10.16438/j.0513-4870.2019-1049
  • Receive Date：2019-12-23
  • Online Date：2026-01-21
  • Published：2020-06-12
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  • Received：2019-12-23
  • Revised：2020-01-10
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    1. Yunnan University of Chinese Medicine, Kunming 650500, China
    2. Key Laboratory of Applied Drug Delivery System and Preparation Technology, Kunming 650500, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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