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Effect and mechanism of IL-6 induced by M2 macrophages on the lung fibroblasts activation
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Fang-zhe ZHAO, Xiao-qing SANG, Yan ZHU, Jian YANG*
Acta Pharmaceutica Sinica | 2020, 55(5) : 892 - 897
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Acta Pharmaceutica Sinica | 2020, 55(5): 892-897
• Original Articles •
Effect and mechanism of IL-6 induced by M2 macrophages on the lung fibroblasts activation
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Fang-zhe ZHAO, Xiao-qing SANG, Yan ZHU, Jian YANG*
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  • State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Published: 2020-05-12 doi: 10.16438/j.0513-4870.2019-1044
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Idiopathic pulmonary fibrosis (IPF) is usually accompanied with inflammatory response, especially the macrophages. The co-culture model of macrophages and fibroblast, and IPF mice model induced by bleomycin were used here to explore the role of macrophages and interleukin-6 (IL-6) in IPF. All animals welfare and experiments were performed following the regulations of the Animal Ethics Committee of Tianjin University of Traditional Chinese Medicine. The results showed that the content of IL-6 in IPF mice induced by bleomycin was significantly increased, and there was a large amount of inflammatory cell infiltration in the lungs. The results of wound-healing and immunofluorescence showed that alternative activated (M2) macrophages could induce the migration and activation of fibroblasts at 36 h, and the expression of IL-6 was increased in the co-culture system. The results of wound-healing and sirius red assay proved that IL-6 could induce the migration and activation of fibroblast. The results showed that M2 macrophages induced fibroblasts to secrete IL-6, thereby inducing the activation and migration of fibroblast, which affect the development of IPF.

idiopathic pulmonary fibrosis  /  macrophage  /  co-culture  /  interleukin-6  /  bleomycin  /  micro computed tomography
Fang-zhe ZHAO, Xiao-qing SANG, Yan ZHU, Jian YANG. Effect and mechanism of IL-6 induced by M2 macrophages on the lung fibroblasts activation[J]. Acta Pharmaceutica Sinica, 2020 , 55 (5) : 892 -897 . DOI: 10.16438/j.0513-4870.2019-1044
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doi: 10.16438/j.0513-4870.2019-1044
  • Receive Date：2019-12-23
  • Online Date：2026-01-21
  • Published：2020-05-12
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  • Received：2019-12-23
  • Revised：2020-01-18
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    State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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