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Advances in Chikungunya virus inhibitors
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Xiang-yi JIANG, jing LI, Xiao-ying WEI, Peng ZHAN*, Xin-yong LIU*
Acta Pharmaceutica Sinica | 2020, 55(4) : 754 - 762
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Acta Pharmaceutica Sinica | 2020, 55(4): 754-762
• Reviews •
Advances in Chikungunya virus inhibitors
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Xiang-yi JIANG, jing LI, Xiao-ying WEI, Peng ZHAN*, Xin-yong LIU*
Affiliations
  • Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Published: 2020-04-12 doi: 10.16438/j.0513-4870.2019-1002
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Chikungunya fever (CHIKF) is an arthropod-borne infection disease caused by Chikungunya virus (CHIKV), which represents a serious health problem worldwide. There is no antiviral drugs treatment for CHIKV infections, neither is there an effective vaccine for prevention of the disease. Herein, we reviewed the recent reported and classical inhibitors of CHIKV, and summarized the medicinal chemistry strategies for discovering CHIKV inhibitors.

Chikungunya fever  /  Chikungunya virus  /  inhibitor  /  antiviral drug  /  medicinal chemistry strategy
Xiang-yi JIANG, jing LI, Xiao-ying WEI, Peng ZHAN, Xin-yong LIU. Advances in Chikungunya virus inhibitors[J]. Acta Pharmaceutica Sinica, 2020 , 55 (4) : 754 -762 . DOI: 10.16438/j.0513-4870.2019-1002
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Article Info
doi: 10.16438/j.0513-4870.2019-1002
  • Receive Date：2019-12-09
  • Online Date：2026-01-20
  • Published：2020-04-12
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History
  • Received：2019-12-09
  • Revised：2019-12-30
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Affiliations
    Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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