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Recent advances in the research of broad-spectrum antiviral agents
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Tian-guang HUANG, Lin SUN, Peng ZHAN*, Xin-yong LIU*
Acta Pharmaceutica Sinica | 2020, 55(4) : 679 - 693
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Acta Pharmaceutica Sinica | 2020, 55(4): 679-693
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Recent advances in the research of broad-spectrum antiviral agents
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Tian-guang HUANG, Lin SUN, Peng ZHAN*, Xin-yong LIU*
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  • Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Published: 2020-04-12 doi: 10.16438/j.0513-4870.2019-0839
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Viral infections have always threatened human health. Broad-spectrum antiviral agents (BSAs) can either target host proteins that are essential for viral replication, or act on multiple viruses or multiple genotypes of the same virus. More importantly, BSAs could reduce the possibility of drug resistance. From the perspective of medicinal chemistry, this review summarizes recent advances in the research of broad-spectrum antiviral drugs with privileged structures or targeting specific targets in the viral life cycle.

broad-spectrum  /  antiviral agent  /  drug target  /  privileged structure
Tian-guang HUANG, Lin SUN, Peng ZHAN, Xin-yong LIU. Recent advances in the research of broad-spectrum antiviral agents[J]. Acta Pharmaceutica Sinica, 2020 , 55 (4) : 679 -693 . DOI: 10.16438/j.0513-4870.2019-0839
Year 2020 volume 55 Issue 4
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doi: 10.16438/j.0513-4870.2019-0839
  • Receive Date:2019-10-24
  • Online Date:2026-01-20
  • Published:2020-04-12
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  • Received:2019-10-24
  • Revised:2019-11-11
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    Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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