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Alkali extraction of Ganoderma lucidum β-glucan and its anti-tumor immune regulation
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Jin-jin ZHANG1, 2, Fei-fei CHEN1, 2, Zhan-peng YAN1, 2, Chang LI1, 2, E SUN1, 2, Yi LUO1, *, Xiao-bin TAN1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(3) : 512 - 521
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Acta Pharmaceutica Sinica | 2020, 55(3): 512-521
• Original Articles •
Alkali extraction of Ganoderma lucidum β-glucan and its anti-tumor immune regulation
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Jin-jin ZHANG1, 2, Fei-fei CHEN1, 2, Zhan-peng YAN1, 2, Chang LI1, 2, E SUN1, 2, Yi LUO1, *, Xiao-bin TAN1, 2, *
Affiliations
  • 1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
  • 2. Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
Published: 2020-03-12 doi: 10.16438/j.0513-4870.2019-0778
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In this study, an immunostimulating particulate β-glucan was isolated from a hot alkaline extract of the fruiting bodies of Ganoderma lucidum. The optimum conditions of 8 hours treatment time, 1:20 solid-liquid ratio and 55℃ for the alkaline extract process were obtained after investigating by single-factor experiments and Box-Benhnken design in terms of the Ganoderma lucidum particulate β-glucan (GLG) increment, and these conditions resulted in a GLG yield of 8.57%. The experimental protocol was approved by the Medical Laboratory Animal Ethics Committee of Jiangsu Provincial Academy of Chinese Medicine. The result showed that resident macrophages were effectively activated by GLG, such as with the up-regulation of co-stimulatory molecules, the secretion of cytokines and phagocytic uptake. GLG could also promote the proliferation of spleen lymphocytes in mice. In addition, IFN-γ production of spleen CD4+T cells and cytotoxic T lymphocyte (CTL) responses were significantly enhanced on GLG orally treatment, which ultimately resulted in significantly decreased tumor burden. Taken together, these data suggest that GLG might act as an immune stimulator to exert antitumor effects.

Ganoderma lucidum  /  β-glucan  /  response surface methodology  /  tumor immunology  /  immunomo-dulatory
Jin-jin ZHANG, Fei-fei CHEN, Zhan-peng YAN, Chang LI, E SUN, Yi LUO, Xiao-bin TAN. Alkali extraction of Ganoderma lucidum β-glucan and its anti-tumor immune regulation[J]. Acta Pharmaceutica Sinica, 2020 , 55 (3) : 512 -521 . DOI: 10.16438/j.0513-4870.2019-0778
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Article Info
doi: 10.16438/j.0513-4870.2019-0778
  • Receive Date：2019-09-25
  • Online Date：2026-01-20
  • Published：2020-03-12
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  • Received：2019-09-25
  • Revised：2019-10-29
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Affiliations
    1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
    2. Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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