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Black phosphorus loaded with zinc ions for enhanced photothermal therapy of prostate cancer
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Li-na SU1, Jin-xie ZHANG2, 3, Ying-hui DENG1, Yun ZHOU3, Chang-fu SHENG1, Lin MEI2, 3, *
Acta Pharmaceutica Sinica | 2020, 55(7) : 1666 - 1671
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Acta Pharmaceutica Sinica | 2020, 55(7): 1666-1671
• Original Articles •
Black phosphorus loaded with zinc ions for enhanced photothermal therapy of prostate cancer
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Li-na SU1, Jin-xie ZHANG2, 3, Ying-hui DENG1, Yun ZHOU3, Chang-fu SHENG1, Lin MEI2, 3, *
Affiliations
  • 1. Department of Pharmacy, Qujing Medical College, Qujing 655000, China
  • 2. Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China
  • 3. School of Pharmaceutical Sciences(Shenzhen), Sun Yat-Sen University, Shenzhen 518107, China
Published: 2020-07-12 doi: 10.16438/j.0513-4870.2019-0771
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Prostate cancer is the most common malignant tumor of male reproductive system, which seriously threatens men's health. It has been shown that the existence of zinc ions can inhibit the growth of prostate cancer cells. In addition, photothermal treatment of cancer is attracting more and more attention due to its high accuracy and efficiency. In this study, zinc ions loaded black phosphorus nanosheets (BP-Zn) were prepared, and the photothermal therapy efficiency of the system on human prostate cancer cells (PC-3) was evaluated. The inhibition effect of zinc ions on PC-3 cells was studied. It was demonstrated that the toxicity of zinc ions on PC-3 cells was concentration- and time-dependent. Moreover, it can be seen from in vitro photothermal therapy that the treatment effect of black phosphorus assisted by zinc ions is superior to that of black phosphorus alone. This study further studied the in vivo therapeutic effect of BP-Zn. The results once again confirmed that the combinational photothermal treatment of zinc ions and BP had excellent anti-tumor effect. The animal procedures were approved by the Animal Ethics Committee of Tsinghua Shenzhen International Graduate School.

photothermal therapy  /  black phosphorus  /  zinc ion  /  prostate cancer  /  combination therapy
Li-na SU, Jin-xie ZHANG, Ying-hui DENG, Yun ZHOU, Chang-fu SHENG, Lin MEI. Black phosphorus loaded with zinc ions for enhanced photothermal therapy of prostate cancer[J]. Acta Pharmaceutica Sinica, 2020 , 55 (7) : 1666 -1671 . DOI: 10.16438/j.0513-4870.2019-0771
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Article Info
doi: 10.16438/j.0513-4870.2019-0771
  • Receive Date：2019-09-23
  • Online Date：2026-01-21
  • Published：2020-07-12
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History
  • Received：2019-09-23
  • Revised：2019-11-10
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Affiliations
    1. Department of Pharmacy, Qujing Medical College, Qujing 655000, China
    2. Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China
    3. School of Pharmaceutical Sciences(Shenzhen), Sun Yat-Sen University, Shenzhen 518107, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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