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Progresses on biological function and targeting vehicles of intestinal Peyer's patches M cells in lymphatic transmission
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Yao-yao DU1, Bing WANG1, 2, Ning ZHANG3, *
Acta Pharmaceutica Sinica | 2020, 55(6) : 1166 - 1174
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Acta Pharmaceutica Sinica | 2020, 55(6): 1166-1174
• Reviews •
Progresses on biological function and targeting vehicles of intestinal Peyer's patches M cells in lymphatic transmission
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Yao-yao DU1, Bing WANG1, 2, Ning ZHANG3, *
Affiliations
  • 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2. Center for Pharmaceutics Research, Shanghai Institute of Materia Medica Chinese, Academy of Sciences, Shanghai 201203, China
  • 3. Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Published: 2020-06-12 doi: 10.16438/j.0513-4870.2019-0739
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Intestinal Peyer's patches (PPs) are important sites to induce mucosal immunity response. As a kind of specialized epithelial cells in PPs, microfold cells (M cells) have a unique ability to take up antigens and can promote systemic immune response by transferring antigens to dendritic cells (DCs) in PPs. Selecting a suitable drug delivery vehicle and modifying the vehicle with a specific ligand can target drugs and bioactive substances to M cells to exert a therapeutic effect on intestinal immune-related diseases. This paper reviews the relevant literatures in the past 20 years, and summarizes and analyzes the ligands, types of vehicles, material properties that target M cells and main factors affecting the uptake of M cells, in order to provide construction ideas and experimental methods that can be worthy of reference for the study of PPs M cells-targeting drug delivery strategies.

mucosal immunity  /  Peyer's patches  /  M cell  /  ligand  /  vehicle
Yao-yao DU, Bing WANG, Ning ZHANG. Progresses on biological function and targeting vehicles of intestinal Peyer's patches M cells in lymphatic transmission[J]. Acta Pharmaceutica Sinica, 2020 , 55 (6) : 1166 -1174 . DOI: 10.16438/j.0513-4870.2019-0739
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Article Info
doi: 10.16438/j.0513-4870.2019-0739
  • Receive Date：2019-09-09
  • Online Date：2026-01-21
  • Published：2020-06-12
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History
  • Received：2019-09-09
  • Revised：2019-11-19
Funding
Affiliations
    1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Center for Pharmaceutics Research, Shanghai Institute of Materia Medica Chinese, Academy of Sciences, Shanghai 201203, China
    3. Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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