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New progress in medicinal chemistry of anti-herpesviruses drug research
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Wen-xiu WEI, Lan-lan JING, Xin-yong LIU*, Peng ZHAN*
Acta Pharmaceutica Sinica | 2020, 55(4) : 575 - 584
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Acta Pharmaceutica Sinica | 2020, 55(4): 575-584
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New progress in medicinal chemistry of anti-herpesviruses drug research
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Wen-xiu WEI, Lan-lan JING, Xin-yong LIU*, Peng ZHAN*
Affiliations
  • Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Published: 2020-04-12 doi: 10.16438/j.0513-4870.2019-0723
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At present, the most widely used anti-herpesviruses drugs are acyclovir (ACV) and its derivatives, but the emergence of herpesvirus resistance to these drugs forces people to continue to seek new anti-herpesviruses drugs. More and more new targets and inhibitors against herpesviruses have been discovered, one reason is the in-depth study of the biological characteristics and pathogenic mechanism of herpesviruses, and the other is the rapid development of new drug design and screening technology. Therefore, there are more options for the treatment of herpes infections. This review summarizes the representative achievements in the field of anti-herpesviruses drugs in recent years.

herpesviruses  /  drug target  /  HHV  /  anti-herpesviruses drug  /  drug design
Wen-xiu WEI, Lan-lan JING, Xin-yong LIU, Peng ZHAN. New progress in medicinal chemistry of anti-herpesviruses drug research[J]. Acta Pharmaceutica Sinica, 2020 , 55 (4) : 575 -584 . DOI: 10.16438/j.0513-4870.2019-0723
Year 2020 volume 55 Issue 4
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doi: 10.16438/j.0513-4870.2019-0723
  • Receive Date:2019-09-06
  • Online Date:2026-01-20
  • Published:2020-04-12
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  • Received:2019-09-06
  • Revised:2019-10-23
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    Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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