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Advances in molecular mechanisms for enhanced hepatic lipogenesis in insulin resistance
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Kai WANG, Xing-feng LIU, Ping-ping LI*
Acta Pharmaceutica Sinica | 2020, 55(2) : 189 - 194
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Acta Pharmaceutica Sinica | 2020, 55(2): 189-194
• Reviews •
Advances in molecular mechanisms for enhanced hepatic lipogenesis in insulin resistance
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Kai WANG, Xing-feng LIU, Ping-ping LI*
Affiliations
  • Diabetes Research Center of Chinese Academy of Medical Sciences, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2020-02-12 doi: 10.16438/j.0513-4870.2019-0718
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Hepatic selective insulin resistance refers to that insulin fails to suppress hepatic glucose production but continues to promote hepatic lipogenesis in insulin resistance. Therefore, type 2 diabetes mellitus is characterized with dyslipidemia apart from hyperglycemia. This review highlights the roles and molecular mechanisms of the key hepatic lipogenesis factors such as sterol regulatory factor binding protein 1c (SREBP1c), mammalian rapamycin target complex 1 (mTORC1), endoplasmic reticulum stress (ER stress), FoxO1, lipid synthesis substrate, etc.

liver  /  insulin resistance  /  de novo lipogenesis  /  lipid metabolism  /  type 2 diabetes
Kai WANG, Xing-feng LIU, Ping-ping LI. Advances in molecular mechanisms for enhanced hepatic lipogenesis in insulin resistance[J]. Acta Pharmaceutica Sinica, 2020 , 55 (2) : 189 -194 . DOI: 10.16438/j.0513-4870.2019-0718
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Article Info
doi: 10.16438/j.0513-4870.2019-0718
  • Receive Date：2019-09-04
  • Online Date：2026-01-20
  • Published：2020-02-12
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  • Received：2019-09-04
  • Revised：2019-10-14
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    Diabetes Research Center of Chinese Academy of Medical Sciences, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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