Home Journals Articles Updates About
CN
image
收藏切换
Research progress of carnitine palmitoyltransferase 1 in tumor immunotherapy
收藏切换
PDF
Ming-yi ZHANG, Ting-ting DU, Ming JI, Xiao-guang CHEN*
Acta Pharmaceutica Sinica | 2019, 54(10) : 1824 - 1830
Less
收藏切换
Acta Pharmaceutica Sinica | 2019, 54(10): 1824-1830
• Reviews •
Research progress of carnitine palmitoyltransferase 1 in tumor immunotherapy
Full
Ming-yi ZHANG, Ting-ting DU, Ming JI, Xiao-guang CHEN*
Affiliations
  • State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2019-10-12 doi: 10.16438/j.0513-4870.2019-0689
Outline
收藏切换

Carnitine palmitoyltransferase 1 (CPT1) is a fatty acid β-oxidative rate-limiting enzyme of fatty acid β-oxidation (FAO) present in the outer membrane of mitochondria, which is closely related to metabolic diseases and tumors. Numerous studies have shown that various subtypes of CPT1 are abnormally expressed in cancer cells and play an important role in resistance to metabolic stress. With the development of tumor immunotherapy, its role in immune cells and organs has also attracted attention. This article aims to review the biological functions of CPT1 and the role of different subtypes in tumor metabolism and immune regulation, and the research progress of its inhibitors, providing new ideas for cancer treatment.

carnitine palmitoyltransferase 1  /  fatty acid β-oxidation  /  tumor  /  immune system  /  metabolism
Ming-yi ZHANG, Ting-ting DU, Ming JI, Xiao-guang CHEN. Research progress of carnitine palmitoyltransferase 1 in tumor immunotherapy[J]. Acta Pharmaceutica Sinica, 2019 , 54 (10) : 1824 -1830 . DOI: 10.16438/j.0513-4870.2019-0689
Appendix
Less
Year 2019 volume 54 Issue 10
PDF
143
61
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2019-0689
  • Receive Date：2019-08-27
  • Online Date：2026-01-26
  • Published：2019-10-12
Article Data
Affiliations
History
  • Received：2019-08-27
  • Revised：2019-09-17
Funding
Affiliations
    State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2019-0689
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House