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Current advances in research on adjuvant therapy for cerebral malaria
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Xiao-hui JIANG1, 2, Zhong-yuan ZHENG1, 2, Hui LIU1, 2, Ting YANG1, 2, Shui-qing QU1, 2, Yu-jie LI1, 2, *, Li-na CHEN1, 2, *
Acta Pharmaceutica Sinica | 2020, 55(2) : 208 - 217
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Acta Pharmaceutica Sinica | 2020, 55(2): 208-217
• Reviews •
Current advances in research on adjuvant therapy for cerebral malaria
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Xiao-hui JIANG1, 2, Zhong-yuan ZHENG1, 2, Hui LIU1, 2, Ting YANG1, 2, Shui-qing QU1, 2, Yu-jie LI1, 2, *, Li-na CHEN1, 2, *
Affiliations
  • 1. Artemisinin Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • 2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
Published: 2020-02-12 doi: 10.16438/j.0513-4870.2019-0677
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Cerebral malaria (CM) is the deadliest complication of Plasmodium falciparum infection and even with effective anti-malarial treatment the mortality of children can be as high as 18%; up to one-third of CM survivors are left with neurological and cognitive deficits. The pathophysiology of CM is not completely understood, but mechanical obstruction and immunopathology are its mainstream theories. Adjuvant therapy aims to improve clinical outcomes and/or reduce mortality, as well as preventing long-term neurocognitive deficits. Improving survival and reducing neurological damage to survivors are new goals for new antimalarials and adjuvant therapies. Herein, we discussed what is known about the disease mechanism of CM and systematically summarize the progress of adjuvant therapy research in protecting the vascular endothelium, reducing adhesion formation, regulating immune balance, interfering with malarial metabolism, protecting nerves, improving nitric oxide bioavailability, improving energy metabolism and alleviating inflammation, with the aim of exploiting this understanding to reduce the neurological damage to children with CM. This work also highlights some preclinical studies which may be candidate strategies in future clinical trials.

cerebral malaria  /  pathogenesis  /  neurological sequelae  /  adjuvant therapy  /  new strategy
Xiao-hui JIANG, Zhong-yuan ZHENG, Hui LIU, Ting YANG, Shui-qing QU, Yu-jie LI, Li-na CHEN. Current advances in research on adjuvant therapy for cerebral malaria[J]. Acta Pharmaceutica Sinica, 2020 , 55 (2) : 208 -217 . DOI: 10.16438/j.0513-4870.2019-0677
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Article Info
doi: 10.16438/j.0513-4870.2019-0677
  • Receive Date：2019-08-26
  • Online Date：2026-01-20
  • Published：2020-02-12
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  • Received：2019-08-26
  • Revised：2019-09-29
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Affiliations
    1. Artemisinin Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China
    2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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