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DEPTOR improves cisplatin chemosensitivity in esophageal squamous cell carcinoma cells by inducing Caspase-1-mediated pyroptosis
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Jing-jing DUAN1, Hui-xin XU1, Pu LUO1, Wen-jun PAN1, Xiao-ying DONG2, Hang ZHENG1, *
Acta Pharmaceutica Sinica | 2019, 54(10) : 1845 - 1850
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Acta Pharmaceutica Sinica | 2019, 54(10): 1845-1850
• Original Articles •
DEPTOR improves cisplatin chemosensitivity in esophageal squamous cell carcinoma cells by inducing Caspase-1-mediated pyroptosis
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Jing-jing DUAN1, Hui-xin XU1, Pu LUO1, Wen-jun PAN1, Xiao-ying DONG2, Hang ZHENG1, *
Affiliations
  • 1. Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • 2. Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Published: 2019-10-12 doi: 10.16438/j.0513-4870.2019-0672
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Chemotherapy resistance is the main cause of poor prognosis in patients with advanced esophageal squamous cell carcinoma (ESCC). Pyroptosis is one of the anti-tumor mechanisms by chemotherapy drugs. Studies have shown that DEP-domain containing mTOR-interacting protein (DEPTOR) is correlated with sorafenib and gefitnib resistance, which is discovered as a naturally negative regulator of mammalian/mechanistic target of rapamicin (mTOR). In this study, DEPTOR knockdown (shDEPTOR) lentivirus was used to establish the stable DEPTOR knockdown ESCC cell lines. The results showed that knockdown of DEPTOR reduced chemosensitivity to cisplatin in ESCC cells in vitro. The lower expression of DEPTOR caused less extensive morphological characteristics of pyroptosis than that was observed in sh-con cells with the treatment of cisplain. Further studies showed that knockdown of DEPTOR induced downregulation of Caspase-1 expression and reduction of Caspase-1 activation, thereby inhibiting the activation of the classical pathway of pyroptosis. This paper demonstrates that DEPTOR can improve cisplatin chemosensitivity in ESCC cells via inducing Caspase-1-mediated pyroptosis.

esophageal squamous cell carcinoma  /  DEP-domain containing mTOR-interacting protein  /  cisplatin chemosensitivity  /  Caspase-1  /  pyroptosis
Jing-jing DUAN, Hui-xin XU, Pu LUO, Wen-jun PAN, Xiao-ying DONG, Hang ZHENG. DEPTOR improves cisplatin chemosensitivity in esophageal squamous cell carcinoma cells by inducing Caspase-1-mediated pyroptosis[J]. Acta Pharmaceutica Sinica, 2019 , 54 (10) : 1845 -1850 . DOI: 10.16438/j.0513-4870.2019-0672
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Article Info
doi: 10.16438/j.0513-4870.2019-0672
  • Receive Date：2019-08-22
  • Online Date：2026-01-26
  • Published：2019-10-12
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  • Received：2019-08-22
  • Revised：2019-09-25
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Affiliations
    1. Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    2. Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
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光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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