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Construction and application of effect-related near-infrared spectroscopy for traditional Chinese medicines-Exemplification by rhubarb dispensing granules
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Ping ZHANG1, *, Ming NIU1, Peng TAN2, 3, Yan-zhong HAN1, 3, Ding-kun ZHANG3, Lei SUN4, Ji-xiang FANG1, Yuan-yuan CUI1, Yan-qin MA1, Shuang-cheng MA4, Yong-feng ZHOU1, *
Acta Pharmaceutica Sinica | 2019, 54(12) : 2162 - 2168
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Acta Pharmaceutica Sinica | 2019, 54(12): 2162-2168
• Special Reports: Biological Evaluation and Precise Control for the Quality of Traditional Chinese Medicines •
Construction and application of effect-related near-infrared spectroscopy for traditional Chinese medicines-Exemplification by rhubarb dispensing granules
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Ping ZHANG1, *, Ming NIU1, Peng TAN2, 3, Yan-zhong HAN1, 3, Ding-kun ZHANG3, Lei SUN4, Ji-xiang FANG1, Yuan-yuan CUI1, Yan-qin MA1, Shuang-cheng MA4, Yong-feng ZHOU1, *
Affiliations
  • 1. The Fifth Medical Center of PLA General Hospital, China Military Institute of Chinese Medicine, Beijing 100039, China
  • 2. Sichuan Academy of Traditional Chinese Medicine, State Key Laboratory of Quality Evaluation of Traditional Chinese Medicine, Chengdu 610041, China
  • 3. Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  • 4. National Institutes for Food and Drug Control, Beijing 100050, China
Published: 2019-12-12 doi: 10.16438/j.0513-4870.2019-0661
Outline
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Consistency in quality of traditional Chinese medicine granules is an important factor to ensure reproducible clinical efficacy. In this study rhubarb dispensing granules were utilized to construct an efficacious near-infrared spectroscopy (eNIRS) assay by combining NIRS and biopotency. A NIR method for assaying rhubarb dispensing particles was established, and information on different batches was collected. The diarrhea-inducing biopotency of rhubarb dispensing granules was determined based on a constipation model induced by diphenoxylate in mice. The animal protocol was approved by the Animal Ethic Committee of 302 Hospital of Chinese PLA People's Liberation Army (ID:IACUC-2019-0010). Ten anthraquinones were determined in rhubarb dispensing granules by UPLC. The correlation between NIR and biopotency was analyzed and five characteristic bands that correlated highly with bioactivity were identified, including 4 011-4 390, 4 859-5 461, 7 012-7 493, 10 992-11 312 and 11 871-12 489 cm-1. There were some differences in the main bands of different chemical constituents. In summary, five active bands based on NIRS were identified and found to be able to achieve rapid on-line detection of rhubarb dispensing granule quality. This research model may also provide reference for quality control of other Chinese medicine dispensing granules.

rhubarb dispensing granule  /  near-infrared spectroscopy  /  biopotency  /  efficacious near-infrared spectroscopy
Ping ZHANG, Ming NIU, Peng TAN, Yan-zhong HAN, Ding-kun ZHANG, Lei SUN, Ji-xiang FANG, Yuan-yuan CUI, Yan-qin MA, Shuang-cheng MA, Yong-feng ZHOU. Construction and application of effect-related near-infrared spectroscopy for traditional Chinese medicines-Exemplification by rhubarb dispensing granules[J]. Acta Pharmaceutica Sinica, 2019 , 54 (12) : 2162 -2168 . DOI: 10.16438/j.0513-4870.2019-0661
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Article Info
doi: 10.16438/j.0513-4870.2019-0661
  • Receive Date：2019-08-22
  • Online Date：2026-01-26
  • Published：2019-12-12
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History
  • Received：2019-08-22
  • Revised：2019-09-14
Funding
Affiliations
    1. The Fifth Medical Center of PLA General Hospital, China Military Institute of Chinese Medicine, Beijing 100039, China
    2. Sichuan Academy of Traditional Chinese Medicine, State Key Laboratory of Quality Evaluation of Traditional Chinese Medicine, Chengdu 610041, China
    3. Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    4. National Institutes for Food and Drug Control, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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