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Research progress of dendritic cells anti-tumor vaccine stimulated by mRNA
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Xing ZHAO1, 2, Yang-zhuo GU1, Xiang-rong SONG1, *
Acta Pharmaceutica Sinica | 2019, 54(10) : 1818 - 1823
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Acta Pharmaceutica Sinica | 2019, 54(10): 1818-1823
• Reviews •
Research progress of dendritic cells anti-tumor vaccine stimulated by mRNA
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Xing ZHAO1, 2, Yang-zhuo GU1, Xiang-rong SONG1, *
Affiliations
  • 1. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
  • 2. Stem Cell and Tissue Engineering Research Center/Key Laboratory of Adult Stem Cell Transformation Research, Chinese Academy of Medical Sciences, Department of Immunology, Guizhou Medical University, Guiyang 550004, China
Published: 2019-10-12 doi: 10.16438/j.0513-4870.2019-0648
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Distinct from conventional cancer therapies focusing directly on local tumors, cancer immunotherapy aims to restore or enhance immune surveillance to fight against cancer, which bears the advantages of less side effects, lasting efficacy, substantial specificity and suitability for individualized treatment. As the most powerful antigen-presenting cell type, dendritic cells (DCs) can induce potent antigen-specific immune responses in vivo. DCs-based immunotherapy acts by loading DCs with cancer antigens in various ways to elicit specific anti-tumor immune responses. Currently, pulsing DCs with cancer antigen encoding mRNAs is an antigen loading approach under extensive study, registering encouraging results in relevant immunotherapeutic clinical trials. Thus, pulsing DCs with mRNAs is a new and highly promising modality in cancer immunotherapy.

dendritic cell  /  mRNA  /  vaccine  /  tumor immunotherapy
Xing ZHAO, Yang-zhuo GU, Xiang-rong SONG. Research progress of dendritic cells anti-tumor vaccine stimulated by mRNA[J]. Acta Pharmaceutica Sinica, 2019 , 54 (10) : 1818 -1823 . DOI: 10.16438/j.0513-4870.2019-0648
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Article Info
doi: 10.16438/j.0513-4870.2019-0648
  • Receive Date：2019-08-13
  • Online Date：2026-01-26
  • Published：2019-10-12
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History
  • Received：2019-08-13
  • Revised：2019-09-17
Funding
Affiliations
    1. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    2. Stem Cell and Tissue Engineering Research Center/Key Laboratory of Adult Stem Cell Transformation Research, Chinese Academy of Medical Sciences, Department of Immunology, Guizhou Medical University, Guiyang 550004, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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