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Role of gut microbiota in the treatment of nonalcoholic fatty liver disease with traditional Chinese medicine
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Xiao-lin LI1, Wei JIANG2, Wei-ming FAN2, Xiao-feng FU2, Lu-lu WANG1, *, Jian-dong JIANG1, *
Acta Pharmaceutica Sinica | 2020, 55(1) : 15 - 24
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Acta Pharmaceutica Sinica | 2020, 55(1): 15-24
• Reviews •
Role of gut microbiota in the treatment of nonalcoholic fatty liver disease with traditional Chinese medicine
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Xiao-lin LI1, Wei JIANG2, Wei-ming FAN2, Xiao-feng FU2, Lu-lu WANG1, *, Jian-dong JIANG1, *
Affiliations
  • 1. Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Institute of Zhejiang Zhenyuan Pharmaceutical Corporation, Shaoxing 312000, China
Published: 2020-01-12 doi: 10.16438/j.0513-4870.2019-0614
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Nonalcoholic fatty liver disease (NAFLD) is a genetic and environmental factor-associated metabolic disease that can lead to fibrosis, cirrhosis and hepatocellular carcinoma. In recent decades the prevalence of NAFLD has increased, but effective pharmacotherapy is limited. Treatment regimens in traditional Chinese medicine (TCM) have made significant contributions to the control of NAFLD, but underlying mechanisms are far less elucidated. Increasing evidence suggests that gut microbiota play a crucial role in the pathogenesis and development of diseases including NAFLD. The outcomes of such research open a new approach in identifying the molecular mechanisms of TCM. Here we review the evidence that gut microbiota might be a target in the treatment NAFLD using TCM.

gut microbiota  /  nonalcoholic fatty liver disease  /  mechanism  /  traditional Chinese medicine
Xiao-lin LI, Wei JIANG, Wei-ming FAN, Xiao-feng FU, Lu-lu WANG, Jian-dong JIANG. Role of gut microbiota in the treatment of nonalcoholic fatty liver disease with traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2020 , 55 (1) : 15 -24 . DOI: 10.16438/j.0513-4870.2019-0614
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Article Info
doi: 10.16438/j.0513-4870.2019-0614
  • Receive Date：2019-07-30
  • Online Date：2026-01-20
  • Published：2020-01-12
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History
  • Received：2019-07-30
  • Revised：2019-09-02
Funding
Affiliations
    1. Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Institute of Zhejiang Zhenyuan Pharmaceutical Corporation, Shaoxing 312000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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