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Research advances in understanding the senescence-associated secretory phenotype and relevant drugs
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Wen-ge ZHENG1, 2, Xue-mei QIN1, Li GAO1, *, Guan-hua DU3, *
Acta Pharmaceutica Sinica | 2020, 55(1) : 8 - 14
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Acta Pharmaceutica Sinica | 2020, 55(1): 8-14
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Research advances in understanding the senescence-associated secretory phenotype and relevant drugs
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Wen-ge ZHENG1, 2, Xue-mei QIN1, Li GAO1, *, Guan-hua DU3, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
Published: 2020-01-12 doi: 10.16438/j.0513-4870.2019-0603
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The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of a series of cytokines such as pro-inflammatory factors, chemokines and proteases, and is a key feature of senescent cells. SASP is a double-edged sword that can resist a harmful environment in normal cells, but with the decline of body function, the massive secretion of cytokines, chemokines and proteases accelerates aging while inducing inflammation, leading to the development of various aging-related diseases. This article reviews the composition and physiological functions of SASP, the changes in SASP during aging, the regulatory pathways associated with SASP, and the anti-aging drugs that regulate SASP. This article aims to present a more comprehensive understanding of SASP and lay the foundation for SASP-based anti-aging research and the discovery of new targets for anti-SASP drugs.

senescence-associated secretory phenotype  /  senescent cell  /  pathway  /  drug
Wen-ge ZHENG, Xue-mei QIN, Li GAO, Guan-hua DU. Research advances in understanding the senescence-associated secretory phenotype and relevant drugs[J]. Acta Pharmaceutica Sinica, 2020 , 55 (1) : 8 -14 . DOI: 10.16438/j.0513-4870.2019-0603
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Article Info
doi: 10.16438/j.0513-4870.2019-0603
  • Receive Date：2019-07-25
  • Online Date：2026-01-20
  • Published：2020-01-12
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History
  • Received：2019-07-25
  • Revised：2019-08-26
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Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
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小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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