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Progress in pharmacokinetics of oral transmucosal drug delivery systems
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Bing WANG1, Hong-rui LIU1, Fang CHEN1, Ying-jun QUAN2, Xiao-qiang XIANG3, *
Acta Pharmaceutica Sinica | 2020, 55(2) : 226 - 234
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Acta Pharmaceutica Sinica | 2020, 55(2): 226-234
• Reviews •
Progress in pharmacokinetics of oral transmucosal drug delivery systems
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Bing WANG1, Hong-rui LIU1, Fang CHEN1, Ying-jun QUAN2, Xiao-qiang XIANG3, *
Affiliations
  • 1. National Pharmaceutical Engineering Research Center, China State Institute of Pharmaceutical Industry, Shanghai 201203, China
  • 2. Fudan University Pudong Medical Center, Shanghai 201300, China
  • 3. School of Pharmacy, Fudan University, Shanghai 201203, China
Published: 2020-02-12 doi: 10.16438/j.0513-4870.2019-0598
Outline
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Oral transmucosal drug delivery can be defined as the administration of drug through the oral mucosa to achieve systemic effects. It has the advantages of high bioavailability and rapid drug response. In this review, we introduce the physiology of oral mucosa, and analyze the factors affecting the pharmacokinetic properties of oral transmucosal drug delivery in detail, such as physiological barriers, different administration sites, physicochemical properties of drugs, dosage forms, and formulation strategies. In addition, we describe the methods to evaluate the pharmacokinetic properties of this delivery systems, including in vitro permeability studies, buccal absorption studies, in vivo pharmacokinetic studies and physiologically based pharmacokinetics (PBPK) modeling, which provide methods and reference for the development of oral transmucosal drug delivery systems.

oral mucosal absorption  /  drug delivery system  /  pharmacokinetics  /  permeability  /  dosage form
Bing WANG, Hong-rui LIU, Fang CHEN, Ying-jun QUAN, Xiao-qiang XIANG. Progress in pharmacokinetics of oral transmucosal drug delivery systems[J]. Acta Pharmaceutica Sinica, 2020 , 55 (2) : 226 -234 . DOI: 10.16438/j.0513-4870.2019-0598
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Article Info
doi: 10.16438/j.0513-4870.2019-0598
  • Receive Date：2019-07-25
  • Online Date：2026-01-20
  • Published：2020-02-12
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History
  • Received：2019-07-25
  • Revised：2019-09-17
Funding
Affiliations
    1. National Pharmaceutical Engineering Research Center, China State Institute of Pharmaceutical Industry, Shanghai 201203, China
    2. Fudan University Pudong Medical Center, Shanghai 201300, China
    3. School of Pharmacy, Fudan University, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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