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The mechanism and research progress of drug resistance of PD-1/PD-L1 immunotherapy in tumors
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Shi-jia YAN, Lei SUN, Guo-hui WAN*
Acta Pharmaceutica Sinica | 2019, 54(10) : 1728 - 1734
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Acta Pharmaceutica Sinica | 2019, 54(10): 1728-1734
• Reviews •
The mechanism and research progress of drug resistance of PD-1/PD-L1 immunotherapy in tumors
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Shi-jia YAN, Lei SUN, Guo-hui WAN*
Affiliations
  • School of Pharmaceutical Sciences, Sun Yat-san University, Guangzhou 510006, China
Published: 2019-10-12 doi: 10.16438/j.0513-4870.2019-0579
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Programmed cell death protein 1 (PD-1) is an important immunosuppressive molecule, which combines with programmed cell death 1 ligand 1 (PD-L1) to initiate programmed T-cell death, leading to immune escape of tumor cells. Immune checkpoint inhibitors kill tumor cells by blocking the binding of PD-1 to PD-L1 and reactivating the patient's own immune system. With the approval of anti-PD-1 monoclonal antibodies nivolumab, pembrolizumab and anti-PD-L1 monoclonal antibody atezolizumab by FDA for the treatment of melanoma, advanced non-small cell lung cancer and other cancers, cancer treatment has ushered in a new dawn. However, only 20% of patients achieved long-term efficacy after treatment, and most patients relapsed later. Therefore, it is significant to identify effective biomarkers and develop new targets to improve the response of patients to immuno-therapy. This article reviews on the mechanism of action of anti-PD-1/PD-L1 drugs in tumors, potential biomarkers and the mechanism of acquired drug resistance, as well as combination therapy under research.

programmed cell death protein 1  /  programmed cell death 1 ligand 1  /  immunotherapy  /  drug re-sistance  /  biomarker
Shi-jia YAN, Lei SUN, Guo-hui WAN. The mechanism and research progress of drug resistance of PD-1/PD-L1 immunotherapy in tumors[J]. Acta Pharmaceutica Sinica, 2019 , 54 (10) : 1728 -1734 . DOI: 10.16438/j.0513-4870.2019-0579
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doi: 10.16438/j.0513-4870.2019-0579
  • Receive Date：2019-07-19
  • Online Date：2026-01-26
  • Published：2019-10-12
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  • Received：2019-07-19
  • Revised：2019-09-04
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    School of Pharmaceutical Sciences, Sun Yat-san University, Guangzhou 510006, China
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光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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