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Anti-cancer activity of two new triterpenes from Brassica rapa
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Lin DU1, 2, Qing-dong HUANG3, Cong-di CHEN1, 2, Tao HAN1, 2, Qi ZHANG1, 2, Wei DU4, *
Acta Pharmaceutica Sinica | 2019, 54(11) : 2049 - 2054
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Acta Pharmaceutica Sinica | 2019, 54(11): 2049-2054
• Special Reports •
Anti-cancer activity of two new triterpenes from Brassica rapa
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Lin DU1, 2, Qing-dong HUANG3, Cong-di CHEN1, 2, Tao HAN1, 2, Qi ZHANG1, 2, Wei DU4, *
Affiliations
  • 1. College of Chemistry and Life Science, Chengdu Normal University, Chengdu 611130, China
  • 2. Institute of Functional Molecules, Chengdu Normal University, Chengdu 611130, China
  • 3. Chengdu Better Pharmaceutical Technology Co., Ltd., Chengdu 611130, China
  • 4. Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Published: 2019-11-12 doi: 10.16438/j.0513-4870.2019-0454
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The chemical constituents from Brassica rapa were identified by various chromatographic techniques including silica gel, reversed-phase silica gel, macroporous resin and Sephadex LH-20 column chromatography. Eight compounds were isolated from this plant. The isolated compounds were elucidated by physicochemical properties and spectroscopic methods, including extensive 1D, 2D-NMR, and HR-ESI-MS techniques. Compounds 1, 2 are new triterpenoids and 3-7 were isolated for the first time from Brassica rapa. The cytotoxic effect of compounds 1 and 2 were tested by MTT assay against five cancer cell lines. The result showed that all compounds exhibit growth inhibition for the cancer lines. Compound 1 has an IC50 value of 5.87 μmol·L-1 for growth inhibition of leukemia cell line HL-60, and IC50 value for compound 2 was 10.32 μmol·L-1.

Tibetan material herb  /  Brassica rapa  /  chemical constituent  /  cytotoxic activity
Lin DU, Qing-dong HUANG, Cong-di CHEN, Tao HAN, Qi ZHANG, Wei DU. Anti-cancer activity of two new triterpenes from Brassica rapa[J]. Acta Pharmaceutica Sinica, 2019 , 54 (11) : 2049 -2054 . DOI: 10.16438/j.0513-4870.2019-0454
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Article Info
doi: 10.16438/j.0513-4870.2019-0454
  • Receive Date：2019-06-10
  • Online Date：2026-01-26
  • Published：2019-11-12
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  • Received：2019-06-10
  • Revised：2019-07-02
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Affiliations
    1. College of Chemistry and Life Science, Chengdu Normal University, Chengdu 611130, China
    2. Institute of Functional Molecules, Chengdu Normal University, Chengdu 611130, China
    3. Chengdu Better Pharmaceutical Technology Co., Ltd., Chengdu 611130, China
    4. Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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