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Effect of carrier size and surface morphology on the aerosolization of formulation in a capsule-based dry powder inhale
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Hu-qi MENG1, Lan CHEN1, 2, *, Dong-hao CHEN2
Acta Pharmaceutica Sinica | 2019, 54(9) : 1673 - 1679
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Acta Pharmaceutica Sinica | 2019, 54(9): 1673-1679
• Original Articles •
Effect of carrier size and surface morphology on the aerosolization of formulation in a capsule-based dry powder inhale
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Hu-qi MENG1, Lan CHEN1, 2, *, Dong-hao CHEN2
Affiliations
  • 1. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
  • 2. Hangzhou Chance Pharmaceuticals Co. Ltd., Hangzhou 311121, China
Published: 2019-09-12 doi: 10.16438/j.0513-4870.2019-0444
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The size and surface morphology of carrier lactose had influence on the aerosolization performance of dry powder inhalers. In this article, chlorpheniramine maleate was blended with two types of commercial carrier lactose, which were Lactohale 100® and Respitose SV003® (SV003), as formulation model. In vitro experiments were conducted using fast screening impactor at 30 L·min-1 and 60 L·min-1 respectively. Meanwhile, computational fluid dynamics (CFD) coupling with discrete element modelling (DEM) was applied to discuss the movements of those two carrier particles in Handihaler® at the flow rate mentioned above. The dispersion characteristics of two formulations and the dispersion mechanism of Handihaler® were analyzed by establishing the relationship between in vitro experiments and numerical simulation. The results of in vitro experiments and CFD-DEM demonstrated that the aerosolization performance of formulation with SV003 was better. The linear correlation (R2=0.940 1) between fine particle dose and total energy loss by carrier collision within the wall of device was found by comparing the in vitro experimental results with CFD-DEM results. It revealed that particle-wall collision in Handihaler® had direct impact on the dispersion results of formulation.

excipient  /  particle size  /  surface property  /  computer simulation  /  dry powder inhaler
Hu-qi MENG, Lan CHEN, Dong-hao CHEN. Effect of carrier size and surface morphology on the aerosolization of formulation in a capsule-based dry powder inhale[J]. Acta Pharmaceutica Sinica, 2019 , 54 (9) : 1673 -1679 . DOI: 10.16438/j.0513-4870.2019-0444
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Article Info
doi: 10.16438/j.0513-4870.2019-0444
  • Receive Date：2019-06-04
  • Online Date：2026-01-26
  • Published：2019-09-12
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History
  • Received：2019-06-04
  • Revised：2019-07-02
Affiliations
    1. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
    2. Hangzhou Chance Pharmaceuticals Co. Ltd., Hangzhou 311121, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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