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Analysis of serum pharmacochemistry from Radix Bupleuri-Radix Paeoniae Alba herb using UPLC-QE-Orbitrap-MS technology
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Qi-cai YIN1, 2, Cong-cong CHEN1, 2, Jun-sheng TIAN1, Xiao-xia GAO1, Xue-mei QIN1, Guan-hua DU1, 3, Yu-zhi ZHOU1, *
Acta Pharmaceutica Sinica | 2019, 54(12) : 2296 - 2302
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Acta Pharmaceutica Sinica | 2019, 54(12): 2296-2302
• Original Articles •
Analysis of serum pharmacochemistry from Radix Bupleuri-Radix Paeoniae Alba herb using UPLC-QE-Orbitrap-MS technology
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Qi-cai YIN1, 2, Cong-cong CHEN1, 2, Jun-sheng TIAN1, Xiao-xia GAO1, Xue-mei QIN1, Guan-hua DU1, 3, Yu-zhi ZHOU1, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2019-12-12 doi: 10.16438/j.0513-4870.2019-0435
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To analyze the chemical profile of Radix Bupleuri-Radix Paeoniae Alba in the serum, after oral absorption of the herbal pair, we used UPLC-QE-Orbitrap-MS technique and Compound Discover 2.0 software to compare the components in the extracts, and drug-containing serum. The map, based on the precise molecular weight and secondary fragment information given by the mass spectrometry, combined with the reference substance and reference information for, finding the chemical components in the blood after oral administration of the herbal pair in the rats. Animal experimentation was approved according to the Committee on the Ethics of Animal Experiments of Shanxi University. The results showed that a total of 55 components were detected in the serum, of which 16 were prototype components and 39 were metabolites of prototype components. UPLC-QE-Orbitrap-MS allows quick, accurate and comprehensive analysis of the blood components of the herb pair after oral administration. This preliminary study of the chemical components in the blood after herb pair ingestion provides a basis for the subsequent research on the pharmacodynamics and drug-drug interactions.

Radix Bupleuri  /  Radix Paeoniae Alba  /  serum pharmacochemistry  /  UPLC-QE-Orbitrap-MS  /  prototype component  /  metabolite
Qi-cai YIN, Cong-cong CHEN, Jun-sheng TIAN, Xiao-xia GAO, Xue-mei QIN, Guan-hua DU, Yu-zhi ZHOU. Analysis of serum pharmacochemistry from Radix Bupleuri-Radix Paeoniae Alba herb using UPLC-QE-Orbitrap-MS technology[J]. Acta Pharmaceutica Sinica, 2019 , 54 (12) : 2296 -2302 . DOI: 10.16438/j.0513-4870.2019-0435
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Article Info
doi: 10.16438/j.0513-4870.2019-0435
  • Receive Date：2019-06-02
  • Online Date：2026-01-26
  • Published：2019-12-12
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  • Received：2019-06-02
  • Revised：2019-07-08
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Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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