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Synthesis and neuroprotective activity of resveratrol-3-n-butylphthalide hybrids
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Yan GAO1, Wan-dong LIU2, Ban-feng RUAN1, *
Acta Pharmaceutica Sinica | 2019, 54(8) : 1461 - 1469
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Acta Pharmaceutica Sinica | 2019, 54(8): 1461-1469
• Original Articles •
Synthesis and neuroprotective activity of resveratrol-3-n-butylphthalide hybrids
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Yan GAO1, Wan-dong LIU2, Ban-feng RUAN1, *
Affiliations
  • 1. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
  • 2. College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Published: 2019-08-12 doi: 10.16438/j.0513-4870.2019-0364
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6-Bromo-3-n-butylphthalide was obtained by nitration, reduction and diazotization from carboxybenzaldehyde. Twenty hybrids from substituted styrene and 6-bromo-3-n-butylphthalide were synthesized and the structure was confirmed by 1H NMR, 13C NMR and ESI-MS. All compounds were evaluated for neuroprotective activity against OGD/R-induced neurotoxicity in rat cortical neurons by MTT assay. The mechanism of neuroprotection was investigated by Western blot analyses. The results indicated that most of these compounds had a potent neuroprotective activity (All animal experiments were approved by the Experimental Animal Ethics Committee of Anhui University of Chinese Medicine), especially 10h and 10i showed significant effects, which may play a neuroprotective role by activating the PI3K/Akt signaling pathway.

resveratrol  /  dl-3-n-butylphthalide  /  synthesis  /  neuroprotection  /  PI3K/Akt
Yan GAO, Wan-dong LIU, Ban-feng RUAN. Synthesis and neuroprotective activity of resveratrol-3-n-butylphthalide hybrids[J]. Acta Pharmaceutica Sinica, 2019 , 54 (8) : 1461 -1469 . DOI: 10.16438/j.0513-4870.2019-0364
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Article Info
doi: 10.16438/j.0513-4870.2019-0364
  • Receive Date：2019-05-13
  • Online Date：2026-01-26
  • Published：2019-08-12
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History
  • Received：2019-05-13
  • Revised：2019-06-10
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    1. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China
    2. College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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