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A new oleanane type triterpenoid from Viburnum taitoense Hayata
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Yun-qiu WU1, Yun-feng HUANG2, Di LUO1, Li QIU1, *, Ji-zhao XIE1, 3, Huan-ji XU1, Xin-duo WU1, Zhe-ming LI1
Acta Pharmaceutica Sinica | 2019, 54(7) : 1260 - 1264
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Acta Pharmaceutica Sinica | 2019, 54(7): 1260-1264
• Original Articles •
A new oleanane type triterpenoid from Viburnum taitoense Hayata
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Yun-qiu WU1, Yun-feng HUANG2, Di LUO1, Li QIU1, *, Ji-zhao XIE1, 3, Huan-ji XU1, Xin-duo WU1, Zhe-ming LI1
Affiliations
  • 1. School of Pharmaceutical Science, Guangxi Medical University, Nanning 530021, China
  • 2. Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning 530022, China
  • 3. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China
Published: 2019-07-12 doi: 10.16438/j.0513-4870.2019-0316
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The chemical constituents of Viburnum taitoense Hayata were investigated using column chromatography silica gel and Sephadex LH-20, etc. Seven pentacyclic triterpenoids were isolated and their structures were elucidated by spectral data and physicochemical properties as 3β, 6β-dihydroxy olean-11, 13(18)-dien-28-acid (1), 3β-hydroxy olean-11, 13(18)-diene-28-acid (2), 12-ene-olean-28-acid-3β-palmitate (3), 3β-acetylcocodiol (4), corosolic acid (5), uvaol (6) and ursolic acid (7). Among them, compound 1 is a new oleanane type triterpenoid and its absolute configuration was confirmed by single-crystal X-ray diffraction data. Compounds 2-5 were isolated from this genus for the first time. All the compounds were evaluated for their anti-inflammatory activities in vitro, and compound 5 showed significant inhibitory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells with an IC50 of 25.52 ±0.56 μmol·L-1 when compared to the positive control, quercetin (IC50 of 25.46 ±0.62 μmol·L-1).

Viburnum  /  V. taitoense Hayata  /  pentacyclic triterpenoid  /  NO  /  RAW264.7
Yun-qiu WU, Yun-feng HUANG, Di LUO, Li QIU, Ji-zhao XIE, Huan-ji XU, Xin-duo WU, Zhe-ming LI. A new oleanane type triterpenoid from Viburnum taitoense Hayata[J]. Acta Pharmaceutica Sinica, 2019 , 54 (7) : 1260 -1264 . DOI: 10.16438/j.0513-4870.2019-0316
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Year 2019 volume 54 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2019-0316
  • Receive Date：2019-04-23
  • Online Date：2026-01-26
  • Published：2019-07-12
Article Data
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History
  • Received：2019-04-23
  • Revised：2019-05-13
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Affiliations
    1. School of Pharmaceutical Science, Guangxi Medical University, Nanning 530021, China
    2. Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning 530022, China
    3. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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