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Mesoporous silica solidifying volatile oil from Bupleuri radix and forsythiae fructus and its micromeritic properties
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Juan-juan TIAN1, Ya-ting YU2, Li-jie ZHAO2, *, Yi FENG2, You-jie WANG2, Lan SHEN1, *
Acta Pharmaceutica Sinica | 2019, 54(8) : 1493 - 1501
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Acta Pharmaceutica Sinica | 2019, 54(8): 1493-1501
• Original Articles •
Mesoporous silica solidifying volatile oil from Bupleuri radix and forsythiae fructus and its micromeritic properties
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Juan-juan TIAN1, Ya-ting YU2, Li-jie ZHAO2, *, Yi FENG2, You-jie WANG2, Lan SHEN1, *
Affiliations
  • 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Published: 2019-08-12 doi: 10.16438/j.0513-4870.2019-0235
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The aim of this study is to solidify the volatile oil (VO) of Bupleuri radix and forsythiae fructus by using mesoporous silica Sylysia 350FCP (Sylysia 350FCP) as carrier, and to investigate the changes of micromeritic properties before and after drug loading. The volatile oil drug-loading powder (VO-DLP) was prepared by blending process. The micromeritic properties were evaluated by angle of repose, particle size, bulk density, true density and porosity. The compressibility and compactibility of the powder were evaluated by plastic strain energy, ejection force, friction energy and tensile strength. The powder was characterized by scanning electron microscopy, powder X-ray diffraction and synchronous thermal analysis. In addition, the thermal stability, mechanical stability and other key properties of VO-DLP were investigated. We found that mesoporous silica as a carrier of solidifying volatile oil has the advantages for large drug load, high thermal stability, and high mechanical stability. In addition, the excellent properties of mesoporous silica as solid lubricant and glidant are not affected after loading VO, and has no effect on the compression process and compactibility of materials. What's more, it can meet the demand of continuous production.

mesoporous silica  /  volatile oil  /  micromeritic property  /  physical characterization  /  stability
Juan-juan TIAN, Ya-ting YU, Li-jie ZHAO, Yi FENG, You-jie WANG, Lan SHEN. Mesoporous silica solidifying volatile oil from Bupleuri radix and forsythiae fructus and its micromeritic properties[J]. Acta Pharmaceutica Sinica, 2019 , 54 (8) : 1493 -1501 . DOI: 10.16438/j.0513-4870.2019-0235
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Article Info
doi: 10.16438/j.0513-4870.2019-0235
  • Receive Date：2019-04-03
  • Online Date：2026-01-26
  • Published：2019-08-12
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  • Received：2019-04-03
  • Revised：2019-05-19
Affiliations
    1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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