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Ideas and strategies from quality evaluation of Radix Bupleurum for development of new anti-depressant drugs
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Xue-mei QIN1, 2, *, Yao GAO1, 2, Jun-sheng TIAN1, 2, Jie XING1, 2, Xiao-xia GAO1, 2, Yu-zhi ZHOU1, 2, Guan-hua DU3
Acta Pharmaceutica Sinica | 2019, 54(8) : 1402 - 1408
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Acta Pharmaceutica Sinica | 2019, 54(8): 1402-1408
• Reviews •
Ideas and strategies from quality evaluation of Radix Bupleurum for development of new anti-depressant drugs
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Xue-mei QIN1, 2, *, Yao GAO1, 2, Jun-sheng TIAN1, 2, Jie XING1, 2, Xiao-xia GAO1, 2, Yu-zhi ZHOU1, 2, Guan-hua DU3
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Shanxi University, Taiyuan 030006, China
  • 3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2019-08-12 doi: 10.16438/j.0513-4870.2019-0229
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Utilization of traditional Chinese medicine (TCM) resources for pharmaceutical development is an important part of modernization of TCM. The classical TCM prescriptions provide an important insight for developing new drugs. Based on the advantages of local TCM resources, focusing on the key scientific problems in the quality evaluation of medicinal materials and the study of classical prescriptions, this research group takes the quality evaluation of medicinal materials as the starting point. Metabolomics serves as a technical means of "quality evaluation of TCM, to support scientific connotation of classical prescriptions and development of new drugs from TCM. Using Radix Bupleurum as an example, this paper systematically and thoroughly expounds the above research ideas and strategies from the aspects:quality evaluation of medicinal materials, basic research of Xiaoyansan, and research and development of new anti-depressants. This provides the scientific basis for the modernization of TCM.

Radix Bupleurum  /  quality evaluation  /  Xiaoyaosan  /  antidepressant  /  new drug research and development  /  research strategy
Xue-mei QIN, Yao GAO, Jun-sheng TIAN, Jie XING, Xiao-xia GAO, Yu-zhi ZHOU, Guan-hua DU. Ideas and strategies from quality evaluation of Radix Bupleurum for development of new anti-depressant drugs[J]. Acta Pharmaceutica Sinica, 2019 , 54 (8) : 1402 -1408 . DOI: 10.16438/j.0513-4870.2019-0229
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Article Info
doi: 10.16438/j.0513-4870.2019-0229
  • Receive Date：2019-04-02
  • Online Date：2026-01-26
  • Published：2019-08-12
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  • Received：2019-04-02
  • Revised：2019-05-10
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Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Shanxi University, Taiyuan 030006, China
    3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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