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Therapeutic effects of artificial musk on acute ischemic stroke and subarachnoid hemorrhage in rats
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Ling WANG1, Jiang LI1, Shao-feng XU1, Nan FENG1, Shu ZHANG2, Xiao-liang WANG1, *
Acta Pharmaceutica Sinica | 2019, 54(6) : 1036 - 1040
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Acta Pharmaceutica Sinica | 2019, 54(6): 1036-1040
• Original Articles •
Therapeutic effects of artificial musk on acute ischemic stroke and subarachnoid hemorrhage in rats
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Ling WANG1, Jiang LI1, Shao-feng XU1, Nan FENG1, Shu ZHANG2, Xiao-liang WANG1, *
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Natural Products and Functions, Beijing 100050, China
  • 2. Beijing Lianxin Pharmaceutical Co., Ltd., Beijing 102628, China
Published: 2019-06-12 doi: 10.16438/j.0513-4870.2019-0198
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The rat models of focal cerebral ischemic reperfusion and subarachnoid hemorrhage were used to evaluate the therapeutic effects of artificial musk to provide support for its clinical application. All animal experiments were performed following the regulations of the Animal Ethics Committee of Peking Union Medical College. The results showed that oral administration of artificial musk had significant protective effects on acute ischemic and hemorrhagic stroke. In the dose range of 10-200 mg·kg-1, the mortality, neurobehavioral and cerebral infarction volume of rats in model group indicated a clear dose dependent relationship. The effective dose of artificial musk is 10 mg·kg-1 in ischemic stroke and 200 mg·kg-1 in hemorrhagic stroke. These findings suggest that the treatments of artificial musk in ischemic stroke and in hemorrhagic stroke are different, and such differences should be noted for its clinical use.

artificial musk  /  stroke  /  cerebral ischemia-reperfusion  /  subarachnoid hemorrhage  /  middle cerebral artery occlusion
Ling WANG, Jiang LI, Shao-feng XU, Nan FENG, Shu ZHANG, Xiao-liang WANG. Therapeutic effects of artificial musk on acute ischemic stroke and subarachnoid hemorrhage in rats[J]. Acta Pharmaceutica Sinica, 2019 , 54 (6) : 1036 -1040 . DOI: 10.16438/j.0513-4870.2019-0198
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Article Info
doi: 10.16438/j.0513-4870.2019-0198
  • Receive Date：2019-03-22
  • Online Date：2026-01-26
  • Published：2019-06-12
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History
  • Received：2019-03-22
  • Revised：2019-04-18
Funding
Affiliations
    1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Natural Products and Functions, Beijing 100050, China
    2. Beijing Lianxin Pharmaceutical Co., Ltd., Beijing 102628, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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