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Synthesis, in vitro evaluation and in vivo imaging of a highly selective hydrazine bioluminescent probe based on luciferin-luciferase system
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Feng XU1, Ao HAI2, Ya-ru MA2, Li-ying QIU2, Min-yong LI1, Lü-pei DU1, *
Acta Pharmaceutica Sinica | 2019, 54(5) : 886 - 891
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Acta Pharmaceutica Sinica | 2019, 54(5): 886-891
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Synthesis, in vitro evaluation and in vivo imaging of a highly selective hydrazine bioluminescent probe based on luciferin-luciferase system
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Feng XU1, Ao HAI2, Ya-ru MA2, Li-ying QIU2, Min-yong LI1, Lü-pei DU1, *
Affiliations
  • 1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(MOE), School of Pharmacy, Shandong University, Jinan 250012, China
  • 2. School of Pharmacy, Southwest Minzu University, Chengdu 610041, China
Published: 2019-05-12 doi: 10.16438/j.0513-4870.2019-0067
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A highly sensitive and selective bioluminescent probe for hydrazine (BPH) was designed, synthe sized and evaluated for detection of hydrazine in vitro and in vivo. BPH was designed to include a specific recogni tion group (acetyl) of hydrazine at an appropriate modification site of the optical reporter hydroxyluciferin (Dluciferin), which showed excellent performance both in selectivity and sensitivity to hydrazine. The results showed that the bioluminescent probe BPH developed in this study is an innovative and widely applicable tool for detecting hydrazine in complex natural environment or in animals.

hydrazine  /  bioluminescent probe for hydrazine  /  D-luciferin  /  small molecule probe  /  in vivo imaging
Feng XU, Ao HAI, Ya-ru MA, Li-ying QIU, Min-yong LI, Lü-pei DU. Synthesis, in vitro evaluation and in vivo imaging of a highly selective hydrazine bioluminescent probe based on luciferin-luciferase system[J]. Acta Pharmaceutica Sinica, 2019 , 54 (5) : 886 -891 . DOI: 10.16438/j.0513-4870.2019-0067
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Article Info
doi: 10.16438/j.0513-4870.2019-0067
  • Receive Date：2019-01-21
  • Online Date：2026-01-26
  • Published：2019-05-12
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History
  • Received：2019-01-21
  • Revised：2019-03-13
Affiliations
    1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(MOE), School of Pharmacy, Shandong University, Jinan 250012, China
    2. School of Pharmacy, Southwest Minzu University, Chengdu 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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