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The progress in the development of HIV inhibitors targeting protein-protein interactions
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Zhao WANG, Desta SAMUEL, Dong-wei KANG, Peng ZHAN, Xin-yong LIU*
Acta Pharmaceutica Sinica | 2019, 54(4) : 620 - 628
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Acta Pharmaceutica Sinica | 2019, 54(4): 620-628
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The progress in the development of HIV inhibitors targeting protein-protein interactions
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Zhao WANG, Desta SAMUEL, Dong-wei KANG, Peng ZHAN, Xin-yong LIU*
Affiliations
  • Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Published: 2019-04-12 doi: 10.16438/j.0513-4870.2019-0050
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Protein-protein interaction (PPI) plays an important role in many steps of the human immunodeficiency virus (HIV) life cycle. Targeting these protein-protein interactions, especially the interaction between the virus with host cells, can provide new insights into the development of HIV inhibitors with novel mechanisms of action. Herein, we review the latest discoveries of PPI inhibitors based on the mechanisms of action of various protein-protein interactions with specific research examples.

AIDS  /  HIV  /  protein-protein interaction  /  inhibitor
Zhao WANG, Desta SAMUEL, Dong-wei KANG, Peng ZHAN, Xin-yong LIU. The progress in the development of HIV inhibitors targeting protein-protein interactions[J]. Acta Pharmaceutica Sinica, 2019 , 54 (4) : 620 -628 . DOI: 10.16438/j.0513-4870.2019-0050
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Article Info
doi: 10.16438/j.0513-4870.2019-0050
  • Receive Date：2019-01-16
  • Online Date：2026-01-26
  • Published：2019-04-12
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  • Received：2019-01-16
  • Revised：2019-01-30
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    Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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