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Advances and applications of lysine acetylation
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Yu-wei YANG, Shuang SHANG, Zhuo-wei HU, Fang HUA*
Acta Pharmaceutica Sinica | 2019, 54(5) : 778 - 787
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Acta Pharmaceutica Sinica | 2019, 54(5): 778-787
• Reviews •
Advances and applications of lysine acetylation
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Yu-wei YANG, Shuang SHANG, Zhuo-wei HU, Fang HUA*
Affiliations
  • State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150), Institute of Meteria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2019-05-12 doi: 10.16438/j.0513-4870.2019-0014
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Protein acetylation is a process of adding an acetyl group to a protein lysine residue with the help of acetyltransferase, which is a pivotal protein post-translational modification linking acetyl-CoA metabolism and cell signal transduction. Recently, the development of mass spectrometry has deepened our understanding of lysine acetylation. Lysine acetylation is involved in many processes such as gene transcription, protein degradation, cellular metabolism, and stress response, which affects biological processes by regulating protein interactions, activity, stability and localization. Protein acetylation is widely happened and plays important regulatory roles in a diversity of human diseases such as metabolic diseases, tumors and cardiovascular diseases. Besides, deacetylase inhibitors have displayed a great potential in the treatment of various diseases especially tumors and metabolic associated diseases. In this review, we summarized the advances and application of acetylation, and discussed the remaining problems in this area.

acetylation  /  metabolism  /  protein modification  /  translational
Yu-wei YANG, Shuang SHANG, Zhuo-wei HU, Fang HUA. Advances and applications of lysine acetylation[J]. Acta Pharmaceutica Sinica, 2019 , 54 (5) : 778 -787 . DOI: 10.16438/j.0513-4870.2019-0014
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Article Info
doi: 10.16438/j.0513-4870.2019-0014
  • Receive Date：2019-01-05
  • Online Date：2026-01-26
  • Published：2019-05-12
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  • Received：2019-01-05
  • Revised：2019-03-05
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    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150), Institute of Meteria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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