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Metabolomic screening for diagnostic biomarkers of drug-induced chronic liver injury related cirrhosis
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Lu-ge WEI1, 2, Xiao-hui WANG2, Ming NIU2, Xiao-yi LIU2, Can TU2, Yuan-yuan ZHOU2, Huangwan-yin HU2, Ya-ming ZHANG2, Hui-fang LI1, Zheng-sheng ZOU3, *, Xiao-he XIAO4, *, Jia-bo WANG2, *
Acta Pharmaceutica Sinica | 2019, 54(8) : 1449 - 1456
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Acta Pharmaceutica Sinica | 2019, 54(8): 1449-1456
• Original Articles •
Metabolomic screening for diagnostic biomarkers of drug-induced chronic liver injury related cirrhosis
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Lu-ge WEI1, 2, Xiao-hui WANG2, Ming NIU2, Xiao-yi LIU2, Can TU2, Yuan-yuan ZHOU2, Huangwan-yin HU2, Ya-ming ZHANG2, Hui-fang LI1, Zheng-sheng ZOU3, *, Xiao-he XIAO4, *, Jia-bo WANG2, *
Affiliations
  • 1. Shanxi University of Traditional Chinese Medicine, Jinzhong 030619, China
  • 2. China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China
  • 3. Treatment and Research Center for Non-infectious Liver Diseases, 302 Military Hospital, Beijing 100039, China
  • 4. Integrative Medicine Center, 302 Military Hospital, Beijing 100039, China
Published: 2019-08-12 doi: 10.16438/j.0513-4870.2018-1059
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About 15%-20% of drug-induced liver injury (DILI) will progress to chronic manifestation (CH-DILI), which sometimes advances rapidly to liver cirrhosis (LC-DILI) within 0.5-1 year with deteriorative clinical prognosis. Therefore, it is important to find a non-invasive diagnosis for early detection of liver cirrhosis. In this study, the metabolomic profiles revealed significant differences in the metabolites from the plasma of LC-DILI versus CH-DILI. We found 35 differential metabolites through principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). Through pathway enrichment analysis, some up-regulated metabolic pathways reflected impaired liver functions such as bile acid, lipid synthesis and decomposition during cirrhosis. Five biomarkers were found to exhibit effective diagnosis value (AUC > 0.6), including phosphatidylcholine, lysoPC (18:1 (9Z)), creatine, taurochenodeoxycholic acid and taurocholic acid. Furthermore, we found that the relative content ratio between phosphatidylcholine and lysoPC (18:1 (9Z)) had a better distinguishing ability (AUC=0.867). The relative content ratio also had the feature to reduce systematic errors of sample processing and instrument detection, therefore having a greater value for clinical application.

drug-induced liver injury  /  chronicity  /  liver cirrhosis  /  metabolomics  /  diagnosis  /  biomarker
Lu-ge WEI, Xiao-hui WANG, Ming NIU, Xiao-yi LIU, Can TU, Yuan-yuan ZHOU, Huangwan-yin HU, Ya-ming ZHANG, Hui-fang LI, Zheng-sheng ZOU, Xiao-he XIAO, Jia-bo WANG. Metabolomic screening for diagnostic biomarkers of drug-induced chronic liver injury related cirrhosis[J]. Acta Pharmaceutica Sinica, 2019 , 54 (8) : 1449 -1456 . DOI: 10.16438/j.0513-4870.2018-1059
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Article Info
doi: 10.16438/j.0513-4870.2018-1059
  • Receive Date：2019-04-26
  • Online Date：2026-01-26
  • Published：2019-08-12
Article Data
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History
  • Received：2019-04-26
  • Revised：2019-06-16
Funding
Affiliations
    1. Shanxi University of Traditional Chinese Medicine, Jinzhong 030619, China
    2. China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China
    3. Treatment and Research Center for Non-infectious Liver Diseases, 302 Military Hospital, Beijing 100039, China
    4. Integrative Medicine Center, 302 Military Hospital, Beijing 100039, China
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表12种不同金属材料的力学参数
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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