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Advances in understanding exosomes-mediated tumor chemoresistance
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Ru-yue ZHANG, Yu-bing ZHOU, Zhe YANG, Jin-xiu GUO, Duo-lu LI*
Acta Pharmaceutica Sinica | 2019, 54(4) : 594 - 600
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Acta Pharmaceutica Sinica | 2019, 54(4): 594-600
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Advances in understanding exosomes-mediated tumor chemoresistance
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Ru-yue ZHANG, Yu-bing ZHOU, Zhe YANG, Jin-xiu GUO, Duo-lu LI*
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  • Henan Key Laboratory for Precision Clinical Pharmacy, Department of Pharmacy, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Published: 2019-04-12 doi: 10.16438/j.0513-4870.2018-1025
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Chemotherapy plays an essential role in controlling tumor growth and progression. However, long-term use of chemotherapeutic drugs usually results in drug resistance in tumor cells, leading to treatment failure and disease progression. The mechanism of tumor resistance to chemotherapy and the strategy of prevention or reversal of such resistance have always been hot issues in cancer therapy research. Exosomes are small spherical vesicles secreted by cells with a diameter of 40-100 nm. They carry a variety of bioactive small molecules (including DNA, ncRNA, RNA, and proteins) and participate in regulation of cell microenvironment, thereby affecting a variety of physiological and pathological activities in the body. In recent years, studies have shown that exosomes play an important role in cancer cell resistance to chemotherapy, metastasis, and immune escape. This article reviews the role and mechanism of exosomes in the development of drug resistance in tumors, and aims to provide new ideas for the prevention or treatment of tumor resistance.

exosomes  /  tumor  /  tumor microenvironment  /  drug resistance
Ru-yue ZHANG, Yu-bing ZHOU, Zhe YANG, Jin-xiu GUO, Duo-lu LI. Advances in understanding exosomes-mediated tumor chemoresistance[J]. Acta Pharmaceutica Sinica, 2019 , 54 (4) : 594 -600 . DOI: 10.16438/j.0513-4870.2018-1025
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doi: 10.16438/j.0513-4870.2018-1025
  • Receive Date：2018-11-13
  • Online Date：2026-01-26
  • Published：2019-04-12
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  • Received：2018-11-13
  • Revised：2018-12-20
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    Henan Key Laboratory for Precision Clinical Pharmacy, Department of Pharmacy, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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