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The mechanism study of protecting kidney of Erzhi Pill based on network pharmacology
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Li ZHUANG1, Yuan-yuan ZHAI1, 2, Wei-feng YAO1, 2, *, Jia XU1, 2, Li FENG1, 2, Bei-hua BAO1, 2, Yu-dan CAO1, 2, Li ZHANG1, 2, An-wei DING1, 2
Acta Pharmaceutica Sinica | 2019, 54(5) : 877 - 885
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Acta Pharmaceutica Sinica | 2019, 54(5): 877-885
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The mechanism study of protecting kidney of Erzhi Pill based on network pharmacology
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Li ZHUANG1, Yuan-yuan ZHAI1, 2, Wei-feng YAO1, 2, *, Jia XU1, 2, Li FENG1, 2, Bei-hua BAO1, 2, Yu-dan CAO1, 2, Li ZHANG1, 2, An-wei DING1, 2
Affiliations
  • 1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Jiangsu Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
Published: 2019-05-12 doi: 10.16438/j.0513-4870.2018-0993
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Based on the concept of network pharmacology, the main nephroprotective components in Erzhi Pill reported in previous studies, were used to predict the targets through the PharmMapper method. Molecular docking was applied to screen for potential targets and biological information annotation databases (DAVID) was used to analyze the molecular function and biological process of the action targets. The Cytoscape software was used to construct the "ingredient-target-pathway" network of Erzhi Pill for renal injury treatment. TTD and GAD database were then applied to screen for the targets of renal disease for building "ingredient-core target" network. We found that 17 major active ingredients of Erzhi Pill regulated 32 targets (including ESR1, ESR2, GCK, MMP3) and affected 6 pathways, such as PI3K-Akt signaling pathway, estrogen signaling pathway and purine metabolism. This study reflected the nature of traditional Chinese medicine as multi-ingredients, multi-targets and multi-path ways, providing new clues for basic science research on the nephroprotective pharmacological mechanism of Erzhi Pill.

network pharmacology  /  molecular docking  /  Erzhi Pill  /  Nvzhenzi  /  Mohanlian  /  protection of kidney
Li ZHUANG, Yuan-yuan ZHAI, Wei-feng YAO, Jia XU, Li FENG, Bei-hua BAO, Yu-dan CAO, Li ZHANG, An-wei DING. The mechanism study of protecting kidney of Erzhi Pill based on network pharmacology[J]. Acta Pharmaceutica Sinica, 2019 , 54 (5) : 877 -885 . DOI: 10.16438/j.0513-4870.2018-0993
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Article Info
doi: 10.16438/j.0513-4870.2018-0993
  • Receive Date：2018-11-01
  • Online Date：2026-01-26
  • Published：2019-05-12
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  • Received：2018-11-01
  • Revised：2018-12-20
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Affiliations
    1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Jiangsu Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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