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A new strategy to intervene tumor metabolism: regulatory targets for amino acid metabolism and advances in drug research
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Hong-li JIANG1, Xue-yang JIANG1, Tong-zhong TANG1, Wen-yuan LIU2, Feng FENG1, Hao-peng SUN3, *, Wei QU1, *
Acta Pharmaceutica Sinica | 2019, 54(3) : 407 - 419
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Acta Pharmaceutica Sinica | 2019, 54(3): 407-419
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A new strategy to intervene tumor metabolism: regulatory targets for amino acid metabolism and advances in drug research
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Hong-li JIANG1, Xue-yang JIANG1, Tong-zhong TANG1, Wen-yuan LIU2, Feng FENG1, Hao-peng SUN3, *, Wei QU1, *
Affiliations
  • 1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210000, China
  • 2. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210000, China
  • 3. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210000, China
Published: 2019-03-12 doi: 10.16438/j.0513-4870.2018-0969
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Reprogramming of metabolism is one of the most critical features in tumorigenesis and tumor growth. Many types of cancer show an increased demand for specific amino acids, rely on exogenous supplies, or alter amino acid metabolic pathways, leading to changes in corresponding amino acid levels to meet the need of tumorigenesis. Therefore, if the level of tumor growth-dependent amino acids can be effectively controlled, a new treatment strategy can be developed from the perspective of cell metabolism. At present, remarkable progress has been made in this field. This paper outlines the amino acid metabolic pathways closely related to tumorigenesis and tumor growth, and summarizes the corresponding regulatory mechanisms and active molecules. Finally, the direction of the field is discussed and prospected for future development.

amino acid metabolism  /  cancer  /  glutamine  /  serine  /  tryptophan  /  metabolic pathway  /  active molecular
Hong-li JIANG, Xue-yang JIANG, Tong-zhong TANG, Wen-yuan LIU, Feng FENG, Hao-peng SUN, Wei QU. A new strategy to intervene tumor metabolism: regulatory targets for amino acid metabolism and advances in drug research[J]. Acta Pharmaceutica Sinica, 2019 , 54 (3) : 407 -419 . DOI: 10.16438/j.0513-4870.2018-0969
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Year 2019 volume 54 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2018-0969
  • Receive Date：2018-10-23
  • Online Date：2026-01-26
  • Published：2019-03-12
Article Data
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History
  • Received：2018-10-23
  • Revised：2018-11-16
Funding
Affiliations
    1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210000, China
    2. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210000, China
    3. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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