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Effects of Scutellaria baicalensis Georgi flowers on D-galactose induced aging in rats based on serum metabolomics
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Jia SONG1, 2, Yi-yuan PANG1, Li GAO1, Xue-mei QIN1, Guan-hua DU1, 3, Yu-zhi ZHOU1, *
Acta Pharmaceutica Sinica | 2019, 54(3) : 533 - 539
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Acta Pharmaceutica Sinica | 2019, 54(3): 533-539
• Original Articles •
Effects of Scutellaria baicalensis Georgi flowers on D-galactose induced aging in rats based on serum metabolomics
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Jia SONG1, 2, Yi-yuan PANG1, Li GAO1, Xue-mei QIN1, Guan-hua DU1, 3, Yu-zhi ZHOU1, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
  • 3. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
Published: 2019-03-12 doi: 10.16438/j.0513-4870.2018-0927
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This study aimed to evaluate the antioxidant activities of Scutellaria baicalensis Georgi flowers by measuring the scavenging activity of hydroxyl radical and superoxide anion radical. Aging of rats was induced by D-galactose and protective effects of Scutellaria flower extract (SFE) at different doses were evaluated by locomotor activities. To explore the mechanism of SFE, metabolomic technique combined with multivariate statistical methods was used to analyze the profile of metabolites from rat serum and quantify the levels of glutamine and glutamate in the serum. All research procedures were approved according to the Committee on the Ethics of Animal Experiments of Shanxi University. The results showed that high-dose of SFE had antioxidant activity in vitro, and could ameliorate the aging behavior of rats. A total of 9 potential biomarkers related to aging were found, pointing to the involvement of 7 metabolic pathways.

Scutellaria baicalensis Georgi flower  /  D-galactose  /  aging  /  metabonomics  /  anti-oxidant in vitro
Jia SONG, Yi-yuan PANG, Li GAO, Xue-mei QIN, Guan-hua DU, Yu-zhi ZHOU. Effects of Scutellaria baicalensis Georgi flowers on D-galactose induced aging in rats based on serum metabolomics[J]. Acta Pharmaceutica Sinica, 2019 , 54 (3) : 533 -539 . DOI: 10.16438/j.0513-4870.2018-0927
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Article Info
doi: 10.16438/j.0513-4870.2018-0927
  • Receive Date：2018-10-11
  • Online Date：2026-01-26
  • Published：2019-03-12
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History
  • Received：2018-10-11
  • Revised：2018-11-29
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Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
    3. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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