Home Journals Articles Updates About
CN
image
收藏切换
Improving the dissolution rate of water-insoluble diflunisal by γ-cyclodextrin metal-organic framework
收藏切换
PDF
Bi-yuan WU, Yi-xian ZHOU, Xin PAN, Gui-lan QUAN*, Chuan-bin WU
Acta Pharmaceutica Sinica | 2019, 54(1) : 29 - 35
Less
收藏切换
Acta Pharmaceutica Sinica | 2019, 54(1): 29-35
• Special Reports: Promoting the Dissolution of Poorly Soluble Drugs •
Improving the dissolution rate of water-insoluble diflunisal by γ-cyclodextrin metal-organic framework
Full
Bi-yuan WU, Yi-xian ZHOU, Xin PAN, Gui-lan QUAN*, Chuan-bin WU
Affiliations
  • School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
Published: 2019-01-12 doi: 10.16438/j.0513-4870.2018-0826
Outline
收藏切换

The aim of this study is to prepare porous γ-cyclodextrin metal-organic framework (CD-MOF) with good biocompatibility to improve the in vitro release properties of water-insoluble drugs. Different sizes of CD-MOF were obtained by controlling the self-assembly of γ-cyclodextrin and potassium ion and the rate of crystal growth. The poorly water-soluble diflunisal (DIF) was selected as the model drug and loaded into the interior of porous CD-MOF by the impregnation method. The DIF loaded CD-MOF (DIF-MOF) was characterized by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), nitrogen adsorption and desorption, Fourier infrared spectrometer and thermogravimetric analysis. In addition, in vitro cytotoxicity and solubilizing capability of CD-MOF were investigated. It revealed that the obtained CD-MOF was cubic-like with a narrow size distribution and high porosity. Negligible cytotoxicity was found after incubation with RAW264.7 cells. Compared with the pure CD-MOF carrier, the morphology and crystal form of DIF-MOF was not damaged during the drug loading process. Moreover, the solubility and release rate of water-insoluble DIF from the DIF-MOF were significantly increased.

cyclodextrin  /  metal-organic framework  /  solubility  /  water-insoluble drug  /  diflunisal
Bi-yuan WU, Yi-xian ZHOU, Xin PAN, Gui-lan QUAN, Chuan-bin WU. Improving the dissolution rate of water-insoluble diflunisal by γ-cyclodextrin metal-organic framework[J]. Acta Pharmaceutica Sinica, 2019 , 54 (1) : 29 -35 . DOI: 10.16438/j.0513-4870.2018-0826
Appendix
Less
Year 2019 volume 54 Issue 1
PDF
137
58
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2018-0826
  • Receive Date：2018-09-10
  • Online Date：2026-01-26
  • Published：2019-01-12
Article Data
Affiliations
History
  • Received：2018-09-10
  • Revised：2018-10-16
Funding
Affiliations
    School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2018-0826
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House