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Mechanism and application of acid-sensitive peptides in drug delivery
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Huan-le ZHAO1, Ju LIANG1, *, Wen-lan WU2, Jun-bo LI1
Acta Pharmaceutica Sinica | 2019, 54(3) : 440 - 447
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Acta Pharmaceutica Sinica | 2019, 54(3): 440-447
• Reviews •
Mechanism and application of acid-sensitive peptides in drug delivery
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Huan-le ZHAO1, Ju LIANG1, *, Wen-lan WU2, Jun-bo LI1
Affiliations
  • 1. Chemical Engineering and Pharmaceutics School, Henan University of Science and Technology, Luoyang 471023, China
  • 2. Medical School, Henan University of Science and Technology, Luoyang 471023, China
Published: 2019-03-12 doi: 10.16438/j.0513-4870.2018-0799
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As a part of novel drug delivery carriers, peptides have diverse biological activities, low immunogenicity and good biocompatibility. In recent years, studies on the delivery carriers modified by peptides have attracted much attention. Among them, the peptides with acid sensitivity can change their secondary structures under slightly acidic microenvironment of the tumor or in lysosome. Therefore, the carriers made or modified by acid-sensitive peptides can specifically release the loaded drug in the tumor tissue, enhance the cell internalization of drugs and improve its therapeutic effects. In accordance with acid-sensitive peptides studied, the side chains, number of polar residues, sequence and secondary structure of the peptides might be involved in the acid sensitivity. In this review, we summarize the acid-sensitive peptides from recent literatures, analyze the connection between the structure and the acid sensitivity, and focus on the mechanism and application of acid-sensitive peptides in drug delivery. This provides the basis for further development and utilization for acid-sensitive peptides for efficient drug delivery.

peptide  /  acid sensitivity  /  carrier  /  drug delivery  /  tumor  /  nano-assemblies
Huan-le ZHAO, Ju LIANG, Wen-lan WU, Jun-bo LI. Mechanism and application of acid-sensitive peptides in drug delivery[J]. Acta Pharmaceutica Sinica, 2019 , 54 (3) : 440 -447 . DOI: 10.16438/j.0513-4870.2018-0799
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Year 2019 volume 54 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2018-0799
  • Receive Date：2018-08-31
  • Online Date：2026-01-26
  • Published：2019-03-12
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History
  • Received：2018-08-31
  • Revised：2018-12-17
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Affiliations
    1. Chemical Engineering and Pharmaceutics School, Henan University of Science and Technology, Luoyang 471023, China
    2. Medical School, Henan University of Science and Technology, Luoyang 471023, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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