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Research advancement in the construction and applications of microfluidic devices for in vitro blood-brain barrier research
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Ying CAI1, 2, Yang CHEN1, Wen-ting ZHOU1, Yue-hua LIAO3, Zhan-ying HONG1, *, Yi-feng CHAI1
Acta Pharmaceutica Sinica | 2019, 54(2) : 269 - 280
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Acta Pharmaceutica Sinica | 2019, 54(2): 269-280
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Research advancement in the construction and applications of microfluidic devices for in vitro blood-brain barrier research
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Ying CAI1, 2, Yang CHEN1, Wen-ting ZHOU1, Yue-hua LIAO3, Zhan-ying HONG1, *, Yi-feng CHAI1
Affiliations
  • 1. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
  • 3. Shanghai University of Medicine & Health Sciences, Shanghai 201318, China
Published: 2019-02-12 doi: 10.16438/j.0513-4870.2018-0773
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The blood-brain barrier (BBB) not only maintains the stability of the environment within the central nervous system by controlling the transport of substances on both sides of the blood and brain, but also plays an important role in the R&D of new drugs for neurological disorders. The establishment of an in vitro high-fidelity model to study BBB function is imperative for assessing barrier permeability of drugs and xenobiotics. However, the complexity of the BBB structure makes it difficult to replicate with an in vitro model. Compared to the traditional in vitro BBB model, the BBB-on-chip provides certain advantages in miniaturizing the system, reducing the amount of cells and medium required, and allowing simultaneously induction of shear stress. We review here the BBB-on-chip models from their establishment and characterization to applications in research of neuroinflammation, brain tumor and drug evaluation.

blood-brain barrier  /  microfluidic chip  /  model establishment  /  characterization  /  application
Ying CAI, Yang CHEN, Wen-ting ZHOU, Yue-hua LIAO, Zhan-ying HONG, Yi-feng CHAI. Research advancement in the construction and applications of microfluidic devices for in vitro blood-brain barrier research[J]. Acta Pharmaceutica Sinica, 2019 , 54 (2) : 269 -280 . DOI: 10.16438/j.0513-4870.2018-0773
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Article Info
doi: 10.16438/j.0513-4870.2018-0773
  • Receive Date：2018-08-23
  • Online Date：2026-01-26
  • Published：2019-02-12
Article Data
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History
  • Received：2018-08-23
  • Revised：2018-11-15
Funding
Affiliations
    1. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
    2. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
    3. Shanghai University of Medicine & Health Sciences, Shanghai 201318, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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