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Delivery of miR-375 and doxorubicin hydrochloride by lipid bilayer coated hollow mesoporous silica nanoparticles for liver cancer therapy
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Zhao-yang YU1, 2, Hui-ying XUE1, Lin QIU1, Yi LIU1, Juan LI1, *
Acta Pharmaceutica Sinica | 2019, 54(1) : 151 - 158
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Acta Pharmaceutica Sinica | 2019, 54(1): 151-158
• ORIGINAL ARTICLES •
Delivery of miR-375 and doxorubicin hydrochloride by lipid bilayer coated hollow mesoporous silica nanoparticles for liver cancer therapy
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Zhao-yang YU1, 2, Hui-ying XUE1, Lin QIU1, Yi LIU1, Juan LI1, *
Affiliations
  • 1. Department of Pharmacy, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China
  • 2. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Published: 2019-01-12 doi: 10.16438/j.0513-4870.2018-0747
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This study was designed to prepare a novel lipid bilayer coated hollow mesoporous silica nanocarrier for co-delivery of gene drugs and chemotherapeutic drugs to enhance the inhibitory activity of antitumor drugs in hepatoma cells. Hollow mesoporous silica was synthesized by modified StÖber method. Lipid-fusion principle was used to prepare lipid-hollow co-loaded doxorubicin (DOX) and miR-375 (LHMSN-DOX/miR-375). Meanwhile, the morphology, particle size, surface potential, drug loading and release were characterized in vitro. The inhibition of cell proliferation, cell migration and invasion was then evaluated. The results indicated that the core-shell structure of LHMSN-DOX/miR-375 was clear with an intact outer lipid membrane and an ordered internal HMSN mesoporous structure. The drug release amount was pH responsive while the drug was rapidly released under simulated intracellular acidic conditions relative to normal physiological environment. Compared with free DOX, LHMSN-DOX/miR-375 can deliver DOX and miR-375 to liver cancer cells and inhibit the proliferation, migration and invasion of cells more effectively.

doxorubicin  /  miR-375  /  drug delivery system  /  hollow mesoporous silicon  /  nanocarrier
Zhao-yang YU, Hui-ying XUE, Lin QIU, Yi LIU, Juan LI. Delivery of miR-375 and doxorubicin hydrochloride by lipid bilayer coated hollow mesoporous silica nanoparticles for liver cancer therapy[J]. Acta Pharmaceutica Sinica, 2019 , 54 (1) : 151 -158 . DOI: 10.16438/j.0513-4870.2018-0747
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Article Info
doi: 10.16438/j.0513-4870.2018-0747
  • Receive Date：2018-08-16
  • Online Date：2026-01-26
  • Published：2019-01-12
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History
  • Received：2018-08-16
  • Revised：2018-09-10
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Affiliations
    1. Department of Pharmacy, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China
    2. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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