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Mechanisms of anti-inflammation of taurochenodeoxycholic acid based on network pharmacology
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Lei LI1, Ba-ya-er TUMEN2, Pei-feng LI3, Chang LIU1, *, Sheng-he LI1, *, Kang-jian NING1, Jin-peng JIANG1
Acta Pharmaceutica Sinica | 2018, 53(12) : 2064 - 2075
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Acta Pharmaceutica Sinica | 2018, 53(12): 2064-2075
• Pharmacology •
Mechanisms of anti-inflammation of taurochenodeoxycholic acid based on network pharmacology
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Lei LI1, Ba-ya-er TUMEN2, Pei-feng LI3, Chang LIU1, *, Sheng-he LI1, *, Kang-jian NING1, Jin-peng JIANG1
Affiliations
  • 1. Key Laboratory of Quality and Safety Control for Pork, Ministry of Agriculture and Rural, College of Animal Science, Anhui Science and Technology University, Fengyang 233100, China
  • 2. Shanxi Animal Disease Control Center, Taiyuan 030027, China
  • 3. Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture and Rual, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China
Published: 2018-12-12 doi: 10.16438/j.0513-4870.2018-0600
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To investigate the anti-inflammatory mechanisms of taurochenodeoxycholic acid (TCDCA), the molecule structure file of TCDCA was downloaded from PubChem database, PharmMapper and GeneCards were used to predict and screen the targets of TCDCA. STRING database and Cytoscape software were used to construct protein interactions network. GO and KEGG analysis was preformed through STRING database. The key targets were validated by molecular docking and the targets type was attributed by DisGeNET database. The network showed that 89 targets were involved in 68 biological processes including response to stimulus, multicellular organismal process, single-multicellular organism process, response to chemical, response to organic substance, by adjusting 51 signaling pathways, such as pathways in cancer, progesterone-mediated oocyte maturation, MAPK signaling pathway, proteoglycans in cancer. These findings provide an overview of anti-inflammation of TCDCA, which reflects the characteristic of multi-targets and multi-pathways of TCDCA. It pointed out the direction for further research on anti-inflammatory mechanism of TCDCA.

taurochenodeoxycholic acid  /  inflammation  /  network pharmacology  /  pharmacological mechanism  /  molecular docking
李磊, 图门巴雅尔, 李培锋, 刘畅, 李升和, 宁康健, 姜锦鹏. 牛磺鹅去氧胆酸抗炎作用机制的网络药理学研究. 药学学报, 2018 , 53 (12) : 2064 -2075 . DOI: 10.16438/j.0513-4870.2018-0600
Lei LI, Ba-ya-er TUMEN, Pei-feng LI, Chang LIU, Sheng-he LI, Kang-jian NING, Jin-peng JIANG. Mechanisms of anti-inflammation of taurochenodeoxycholic acid based on network pharmacology[J]. Acta Pharmaceutica Sinica, 2018 , 53 (12) : 2064 -2075 . DOI: 10.16438/j.0513-4870.2018-0600
Appendix
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Year 2018 volume 53 Issue 12
532
249
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Article Info
doi: 10.16438/j.0513-4870.2018-0600
  • Receive Date：2018-07-01
  • Online Date：2026-01-15
  • Published：2018-12-12
Article Data
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History
  • Received：2018-07-01
  • Revised：2018-07-31
Funding
Affiliations
    1. Key Laboratory of Quality and Safety Control for Pork, Ministry of Agriculture and Rural, College of Animal Science, Anhui Science and Technology University, Fengyang 233100, China
    2. Shanxi Animal Disease Control Center, Taiyuan 030027, China
    3. Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture and Rual, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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