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Study on Radix Scrophulariae for the treatment of hyperthyroidism rat model of yin deficiency based on urine metabonomics
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Ning ZHANG1, 2, Zi-hui LI1, Hong-wei ZHAO1, Mu PANG1, Shu-min LIU3, *
Acta Pharmaceutica Sinica | 2018, 53(11) : 1843 - 1851
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Acta Pharmaceutica Sinica | 2018, 53(11): 1843-1851
• Pharmacology •
Study on Radix Scrophulariae for the treatment of hyperthyroidism rat model of yin deficiency based on urine metabonomics
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Ning ZHANG1, 2, Zi-hui LI1, Hong-wei ZHAO1, Mu PANG1, Shu-min LIU3, *
Affiliations
  • 1. Heilongjiang University of Chinese Medicine, Harbin 150040, China
  • 2. First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang 550001, China
  • 3. Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin 150040, China
Published: 2018-11-12 doi: 10.16438/j.0513-4870.2018-0479
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The Chinese herbal Radix Scrophulariae is the main medicine for nourishing yin and reducing fire. It can be used to treat hyperthyroidism due to yin deficiency and fire hyperactivity, but its mechanism is not clear. The present study was aimed to explore the mechanism of Radix Scrophulariae treatment of hyperthyroidism due to yin deficiency and fire hyperactivity. The urine metabolomic approach was conducted using the method of UPLC-TOF-MS. The results showed that Radix Scrophulariae has good therapeutic effects on hyperthyroidism rat model of yin deficiency. After treatment with Radix Scrophulariae, through metabolic profiling and protocol analysis, 6 potential metabolic markers may be closely related with the treatment mechanism of Radix Scrophulariae on this disease, including proline betaine, estrone, thymidine, 5-hydroxyindoleacetic acid, cyclic AMP and L-dopa. The strongest metabolic pathways were associated with tryptophan metabolism, pyrimidine metabolism, tyrosine metabolism, purine metabolism and steroid hormone biosynthesis. The urine metabolomic approach can be applied to clarify the therapeutic mechanism of Radix Scrophulariae on hyperthyroidism rat of yin deficiency, and provide the theoretical basis for the clinical practice of Radix Scrophulariae on nourishing yin to reduce pathogenic fire.

Radix Scrophulariae  /  hyperthyroidism rat model of yin deficiency  /  nourishing yin to reduce pathogenic fire  /  metabonomics
Ning ZHANG, Zi-hui LI, Hong-wei ZHAO, Mu PANG, Shu-min LIU. Study on Radix Scrophulariae for the treatment of hyperthyroidism rat model of yin deficiency based on urine metabonomics[J]. Acta Pharmaceutica Sinica, 2018 , 53 (11) : 1843 -1851 . DOI: 10.16438/j.0513-4870.2018-0479
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Year 2018 volume 53 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2018-0479
  • Receive Date：2018-05-23
  • Online Date：2026-01-15
  • Published：2018-11-12
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History
  • Received：2018-05-23
  • Revised：2018-07-21
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Affiliations
    1. Heilongjiang University of Chinese Medicine, Harbin 150040, China
    2. First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang 550001, China
    3. Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin 150040, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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