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Preparation and characterization of timolol maleate cubic nanoparticles for ocular administration
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Qing-qing WANG1, *, Ming-long CHEN1, 2, Xia HU1, Na XIE1, Qi-xia LIU1, Rui SUN1, Na ZHU1, Chuan-bin WU2
Acta Pharmaceutica Sinica | 2018, 53(11) : 1894 - 1900
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Acta Pharmaceutica Sinica | 2018, 53(11): 1894-1900
• ORIGINAL ARTICLES •
Preparation and characterization of timolol maleate cubic nanoparticles for ocular administration
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Qing-qing WANG1, *, Ming-long CHEN1, 2, Xia HU1, Na XIE1, Qi-xia LIU1, Rui SUN1, Na ZHU1, Chuan-bin WU2
Affiliations
  • 1. Faculty of Pharmacy, Bengbu Medical College, Bengbu 233030, China
  • 2. School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou 510006, China
Published: 2018-11-12 doi: 10.16438/j.0513-4870.2018-0475
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Timolol maleate cubic nanoparticles (TM-LCNPs) were prepared via fragmentation of a bulk GMO/poloxamer 407 cubic phase gel by high-pressure homogenization. The optimal prescription was selected based on particle size and entrapment efficiency by orthogonal design method. Malvern particle sizer, polarized light microscopy, and differential scanning calorimetry were used to characterize the cubic nanoparticles. Commercial eye drops were used as a control for the release and corneal permeation experiment in vitro. Fluorescence imaging was used to observe the retention of Rhodamine B cubic nanoparticles (RhB-LCNPs) in rabbit cornea. The results indicated that the optimal prescription and preparation of TM-LCNPs was oil-water ratio (7:3), homogenous pressure (900 bar), the number of homogenizations (6) and drug loading (1%). Corneal permeability of TM-LCNPs was significantly higher than that of commercially available eye drops. The residence time in eyes was longer which suggested a sustained release behavior. The pathology result of rabbit corneal after multiple administration of TM-LCNPs showed that there was no apparent damage.

timolol maleate  /  cubosome  /  nanoparticle  /  ocular administration
Qing-qing WANG, Ming-long CHEN, Xia HU, Na XIE, Qi-xia LIU, Rui SUN, Na ZHU, Chuan-bin WU. Preparation and characterization of timolol maleate cubic nanoparticles for ocular administration[J]. Acta Pharmaceutica Sinica, 2018 , 53 (11) : 1894 -1900 . DOI: 10.16438/j.0513-4870.2018-0475
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Article Info
doi: 10.16438/j.0513-4870.2018-0475
  • Receive Date：2018-05-21
  • Online Date：2026-01-15
  • Published：2018-11-12
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  • Received：2018-05-21
  • Revised：2018-06-21
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    1. Faculty of Pharmacy, Bengbu Medical College, Bengbu 233030, China
    2. School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou 510006, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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