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Metabolism of saponins from traditional Chinese medicines: a review
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Wei SONG1, Wei ZHENG2, Jie ZHANG2, Tao ZHANG3, Shu-chen LIU2, Li-yan YU3, Bai-ping MA2, *
Acta Pharmaceutica Sinica | 2018, 53(10) : 1609 - 1619
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Acta Pharmaceutica Sinica | 2018, 53(10): 1609-1619
• REVIEWS •
Metabolism of saponins from traditional Chinese medicines: a review
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Wei SONG1, Wei ZHENG2, Jie ZHANG2, Tao ZHANG3, Shu-chen LIU2, Li-yan YU3, Bai-ping MA2, *
Affiliations
  • 1. Center for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
  • 2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
  • 3. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2018-10-12 doi: 10.16438/j.0513-4870.2018-0470
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Saponins are important components in traditional Chinese medicine (TCM) with significant biological activities, which could be divided into triterpenoid saponins and steroidal saponins according to structures of the aglycone skeletons. This article reviews the in vivo metabolic pathways of some typical natural saponins such as ginsenosides, licorice saponins, saikosaponins, timosaponins and diosgenin glycosides. Saponins often show poor absorbance after oral administration. The in vivo metabolism of saponins generally contain two steps. These compounds usually undergo hydrolysis in stomach and gut. Then they are absorbed into blood and metabolized in liver. The secondary glycosides and the aglycones produced in gastrointestinal tract often show higher bioavailability and better bioactivity, while downstream metabolites in liver are mainly produced by phase Ⅰ metabolism. Clarification of the in vivo metabolism of bioactive saponins is helpful for the understanding of the effective ingredients in TCM, as well as the discovery of new drugs from natural products.

traditional Chinese medicine  /  triterpenoid saponins  /  steroidal saponins  /  in vivo metabolism  /  gut bacteria  /  phase Ⅰ metabolism
Wei SONG, Wei ZHENG, Jie ZHANG, Tao ZHANG, Shu-chen LIU, Li-yan YU, Bai-ping MA. Metabolism of saponins from traditional Chinese medicines: a review[J]. Acta Pharmaceutica Sinica, 2018 , 53 (10) : 1609 -1619 . DOI: 10.16438/j.0513-4870.2018-0470
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Article Info
doi: 10.16438/j.0513-4870.2018-0470
  • Receive Date：2018-05-19
  • Online Date：2026-01-15
  • Published：2018-10-12
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History
  • Received：2018-05-19
  • Revised：2018-07-03
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Affiliations
    1. Center for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
    3. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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