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Elevated glucocorticoid damages gap junction structure and function in rat prefrontal cortex
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Yu-xia LOU1, 2, Jing LI2, Cong-yuan XIA2, Zhen-zhen WANG2, Nai-hong CHEN1, 2, *
Acta Pharmaceutica Sinica | 2018, 53(10) : 1645 - 1651
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Acta Pharmaceutica Sinica | 2018, 53(10): 1645-1651
• ORIGINAL ARTICLES •
Elevated glucocorticoid damages gap junction structure and function in rat prefrontal cortex
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Yu-xia LOU1, 2, Jing LI2, Cong-yuan XIA2, Zhen-zhen WANG2, Nai-hong CHEN1, 2, *
Affiliations
  • 1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • 2. State Key Laboratory of Bioactive Substances and Functions of Natural Medicine, Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
Published: 2018-10-12 doi: 10.16438/j.0513-4870.2018-0436
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In this article, we exogenously administered glucocorticoids to rats, observed changes in the structure and function of gap junctions in the prefrontal cortex (PFC) and studied the effects of glucocorticoid receptor (GR) inhibitor mifepristone on these changes. Subcutaneous injection of corticosterone (CORT) was used to increase glucocorticoid levels in rats, intragastric administration of mifepristone antagonist GR. Sucrose preference test was conducted to evaluate anhedonia. Dye transfer assay and electron microscopy were used to analyze the function and ultrastructural changes of gap junctions in astrocytes of PFC. Immunofluorescence was used to detect the expression of connexin 43 (Cx43). Animals exposed to CORT showed behavioral deficits in sucrose preference test, exhibited significant decreases in diffusion of gap junction channel-permeable dye and abnormal gap junctional ultrastructure, as well as reductions in Cx43 puncta density in the PFC. The behavioral and cellular alterations induced by CORT were reversed or blocked by treatment with the GR antagonist mifepristone. The results suggest that mifepristone can improve the gap junction function and structural damage of astrocytes in the PFC of depressive rats induced by CORT. In conclusion, the activation of the GR receptor may contribute to gap junction dysfunction in the PFC.

gap junction  /  mifepristone  /  prefrontal cortex  /  glucocorticoid  /  depression
Yu-xia LOU, Jing LI, Cong-yuan XIA, Zhen-zhen WANG, Nai-hong CHEN. Elevated glucocorticoid damages gap junction structure and function in rat prefrontal cortex[J]. Acta Pharmaceutica Sinica, 2018 , 53 (10) : 1645 -1651 . DOI: 10.16438/j.0513-4870.2018-0436
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Article Info
doi: 10.16438/j.0513-4870.2018-0436
  • Receive Date：2018-05-11
  • Online Date：2026-01-15
  • Published：2018-10-12
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  • Received：2018-05-11
  • Revised：2018-06-19
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    1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    2. State Key Laboratory of Bioactive Substances and Functions of Natural Medicine, Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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