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Research progress of indoleamine 2, 3-dioxygenase 1 in tumor immunotherapy
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Ting-ting DU, Fang-fang LAI, Xiao-guang CHEN*
Acta Pharmaceutica Sinica | 2018, 53(8) : 1271 - 1278
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Acta Pharmaceutica Sinica | 2018, 53(8): 1271-1278
• REVIEWS •
Research progress of indoleamine 2, 3-dioxygenase 1 in tumor immunotherapy
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Ting-ting DU, Fang-fang LAI, Xiao-guang CHEN*
Affiliations
  • State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2018-08-12 doi: 10.16438/j.0513-4870.2018-0417
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IDO1 (indoleamine 2, 3-dioxygenase 1) is one of the most significant checkpoint in tumor immunology. Numerous studies indicates that IDO1 is abnormally expressed in breast cancer, colorectal cancer, liver cancer and other tumor tissues, participating in tumor immune escape through multiple pathways. This review is prepared to elucidate the biological function of IDO1, highlight its pivotal role in tumor evasion, and summarize IDO1 inhibitors in the clinical trials.

indoleamine 2, 3-dioxygenase 1  /  immunotherapy  /  tumor escape
Ting-ting DU, Fang-fang LAI, Xiao-guang CHEN. Research progress of indoleamine 2, 3-dioxygenase 1 in tumor immunotherapy[J]. Acta Pharmaceutica Sinica, 2018 , 53 (8) : 1271 -1278 . DOI: 10.16438/j.0513-4870.2018-0417
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Article Info
doi: 10.16438/j.0513-4870.2018-0417
  • Receive Date：2018-05-06
  • Online Date：2026-01-15
  • Published：2018-08-12
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  • Received：2018-05-06
  • Revised：2018-05-30
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    State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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