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Hydroxysafflor yellow A repairing the metabolic disturbances of early atherosclerosis based on fatty acid profiling
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Zi-yi WEI1, 2, Wen-juan XU2, 3, Jiao-jiao DONG1, 2, Jie LIU2, 4, Zhi-xin JIA2, 4, Yi-jun CHEN1, 2, Ming-xia WANG1, 2, Jiao YANG1, 2, Hong-bin XIAO2, 4, *
Acta Pharmaceutica Sinica | 2018, 53(10) : 1680 - 1688
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Acta Pharmaceutica Sinica | 2018, 53(10): 1680-1688
• Pharmacology •
Hydroxysafflor yellow A repairing the metabolic disturbances of early atherosclerosis based on fatty acid profiling
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Zi-yi WEI1, 2, Wen-juan XU2, 3, Jiao-jiao DONG1, 2, Jie LIU2, 4, Zhi-xin JIA2, 4, Yi-jun CHEN1, 2, Ming-xia WANG1, 2, Jiao YANG1, 2, Hong-bin XIAO2, 4, *
Affiliations
  • 1. Schoolof Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
  • 2. Research Center for Chinese Medicine Analysis and Transformation, Beijing University of Chinese Medicine, Beijing 100029, China
  • 3. School of Life Science, Beijing University of Chinese Medicine, Beijing 100029, China
  • 4. Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Published: 2018-10-12 doi: 10.16438/j.0513-4870.2018-0409
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Atherosclerosis (AS) is a complex metabolic syndrome that seriously harms human health, and its occurrence and development are directly related to the metabolic disturbances of free fatty acids (FFA). In this study, macrophage-derived foam cells were established as the model of early AS. Therefore, the metabolic disturbances of FFA in ox-LDL induced foamy macrophages were analyzed using target metabolomics. Then the effect of hydroxysafflor yellow A (HSYA) on regulating FFA was also explored. The quantitative analysis of 27 fatty acids was obtained within 20 min based on dynamic MRM mode. Thirteen metabolic biomarkers of macrophage-derived foam cells were identified using multivariate statistical analysis. It was found that upregulation of total SFA and downregulation of C12:0, C14:0, C18:1, total MUFA were the typical metabolic features in macrophage-derived foam cells. Furthermore, HSYA displayed obvious repairing effect on C12:0, C14:0 and C18:1, which were involved in de novo fatty acid biosynthesis pathway. Oleoyl-(acyl-carrier-protein) hydrolase (OLAH), as the key enzyme in de novo fatty acid biosynthesis pathway, may be a drug target of HSYA.

metabolomics  /  free fatty acid  /  macrophage-derived foam cell  /  atherosclerosis  /  hydroxysafflor yellow A  /  de novo fatty acid biosynthesis
Zi-yi WEI, Wen-juan XU, Jiao-jiao DONG, Jie LIU, Zhi-xin JIA, Yi-jun CHEN, Ming-xia WANG, Jiao YANG, Hong-bin XIAO. Hydroxysafflor yellow A repairing the metabolic disturbances of early atherosclerosis based on fatty acid profiling[J]. Acta Pharmaceutica Sinica, 2018 , 53 (10) : 1680 -1688 . DOI: 10.16438/j.0513-4870.2018-0409
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Article Info
doi: 10.16438/j.0513-4870.2018-0409
  • Receive Date：2018-06-03
  • Online Date：2026-01-15
  • Published：2018-10-12
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History
  • Received：2018-06-03
  • Revised：2018-07-31
Funding
Affiliations
    1. Schoolof Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
    2. Research Center for Chinese Medicine Analysis and Transformation, Beijing University of Chinese Medicine, Beijing 100029, China
    3. School of Life Science, Beijing University of Chinese Medicine, Beijing 100029, China
    4. Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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