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Exploration of "principle-recipe-composition-target-activity" association of Bupleuri Radix and Scutellariae Radix drug pair for diabetes treatment based on network pharmacology
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Hai-yan XU1, Xiu-juan PENG1, Yan-bin CHEN2, Gang XU2, Li LU1, Min-na HOU1, Yan-hong LIU1, Feng LIU1, 2, *, Hai-yu XU1, 3, *
Acta Pharmaceutica Sinica | 2018, 53(9) : 1414 - 1421
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Acta Pharmaceutica Sinica | 2018, 53(9): 1414-1421
• SPECIAL REPORTS •
Exploration of "principle-recipe-composition-target-activity" association of Bupleuri Radix and Scutellariae Radix drug pair for diabetes treatment based on network pharmacology
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Hai-yan XU1, Xiu-juan PENG1, Yan-bin CHEN2, Gang XU2, Li LU1, Min-na HOU1, Yan-hong LIU1, Feng LIU1, 2, *, Hai-yu XU1, 3, *
Affiliations
  • 1. Shaanxi Institute of International Trade and Commerce, Xianyang 712046, China
  • 2. Shaanxi Buchang Pharmaceutical Co., Ltd., Xi'an 710075, China
  • 3. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
Published: 2018-09-15 doi: 10.16438/j.0513-4870.2018-0354
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By using the integrated pharmacology platform and the big data of traditional Chinese medicine combined with the pharmacology thinking of "principle-recipe-composition-target-pathway-activity" in this study, we predicted the material basis and mechanisms of Bupleuri Radix and Scutellariae Radix drug pair for the treatment of diabetes. Fifty-nine active components were predicted, which included saponins, flavones, essential oil, fatty acids and so on. They acted on twenty-two direct targets and twenty-six main pathways respectively.The known disease targets of diabetes include arginine vasopressin receptor gene (AVP), retinoblastoma (RB1), receptor active modified protein (RAMP), platelet growth factor receptor (PDGFR), insulin receptor (INSR), α-glucosidase (GAA), etc. The pathways with diabetes effect involves endocrine system, circulatory system, digestive system, thyroid hormone signaling pathway, ErbB signaling pathway, PI3K-Akt signaling pathway, lipid metabolism and other related biological processes and metabolic pathways. The results of virtual screening in molecular docking technology indicate that flavonoids from Bupleuri Radix and Scutellariae Radix drug pair can easily form good docking mode and high affinity with peroxisome proliferators activated receptor γ (PPAR-γ) and glycogen synthase kinase-3β (GSK-3β), showing antidiabetic activity. The study provides information for the treatment of diabetes by Bupleuri Radix and Scutellariae Radix drug pair, and a new thought for the study of drug pair and complex prescription.

network pharmacology  /  Bupleuri Radix and Scutellariae Radix  /  drug pair  /  diabetes  /  principlerecipe-composition-target-activity
Hai-yan XU, Xiu-juan PENG, Yan-bin CHEN, Gang XU, Li LU, Min-na HOU, Yan-hong LIU, Feng LIU, Hai-yu XU. Exploration of "principle-recipe-composition-target-activity" association of Bupleuri Radix and Scutellariae Radix drug pair for diabetes treatment based on network pharmacology[J]. Acta Pharmaceutica Sinica, 2018 , 53 (9) : 1414 -1421 . DOI: 10.16438/j.0513-4870.2018-0354
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Year 2018 volume 53 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2018-0354
  • Receive Date：2018-04-17
  • Online Date：2026-01-15
  • Published：2018-09-15
Article Data
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History
  • Received：2018-04-17
  • Revised：2018-06-04
Funding
Affiliations
    1. Shaanxi Institute of International Trade and Commerce, Xianyang 712046, China
    2. Shaanxi Buchang Pharmaceutical Co., Ltd., Xi'an 710075, China
    3. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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